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Medical Science Technology is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of applied technology in medicine and biomedical research. It is aimed at readers and authors with their main interest in the application of technology to solve problems in the medical and biological sciences, and overlapping areas of medicine and technology, such as (but not limited... read more

Published: 2017-02-10

Effects of Pollen Typhae Flavonoids on Atherosclerosis in ApoE–/– Mice

Ruo-lan Huang, Xiao-zhu Liu, Yin-feng Li, Ling Wang, Lai-qing Li, Xiao Chang, Li-jun Ou, Ming-tai Chen, Zhong Zhang

(Department of Intensive Care Uni (ICU), Shenzhen Chinese Traditional Medical Hospital, Shenzhen, Guangdong, China (mainland))

Med Sci Tech 2017; 57:1-9

DOI: 10.12659/MST.903286

BACKGROUND: Atherosclerosis is a systemic disease with focal rupture of vulnerable plaque and is responsible for major clinical events. Vascular smooth muscle cells play key roles in the progression of atherosclerosis. Pollen Typhae flavone is a traditional Chinese herb and had been used to treat many diseases. However, effects of pollen Typhae flavonoids on atherosclerosis are unclear. In this study, ApoE–/– mice were fed with high-fat chow to build an atherosclerosis model.
MATERIAL AND METHODS: Different doses of pollen Typhae flavone treatments were used to investigate the effects of pollen Typhae flavonoids on atherosclerosis.
RESULTS: Results showed that medium-dose and high-dose pollen Typhae flavonoids reduced atherosclerosis lesion area in ApoE–/– mice. Pollen Typhae flavonoids also significantly altered plasma lipid levels, including total cholesterol, triglyceride, LDL, and homocysteine. Furthermore, medium-dose and high-dose pollen Typhae flavonoid relieved endoplasmic reticulum stress and lessened inflammation and apoptosis in vulnerable plaque.
CONCLUSIONS: Pollen Typhae flavonoids are effective in alleviating atherosclerosis by relieving endoplasmic reticulum stress-initiated apoptosis in vascular smooth muscle cells.

Keywords: atherosclerosis, Intracranial Arteriosclerosis, Orthodontic Appliances, Functional

Published: 2016-12-23

Sepsis-Induced Cholestasis is Associated with Increased Rates of Complications and 1-Year Mortality in Pa...

Juan-Juan Wu, He-Bin Fan, Ya-Bing Guo, Dong-Liang Yang, Chang-Li Zhang, Jun Xiao, Jie Sun, Lu Huang, Zhi Li, Li-Tong Xu, Fu-Ming Yan

Med Sci Tech 2016; 57:116-121

DOI: 10.12659/MST.902027

Published: 2016-10-28

Treatment of Depression in Patients with Diabetes Mellitus: A Review

Katarzyna Pietrzyk-Orkisz, Katarzyna Józefacka-Majewska, Marlena Zajączkowska, Piotr Gałecki

Med Sci Tech 2016; 57:110-115

DOI: 10.12659/MST.900780