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Medical Science & Technology is an open access, peer-reviewed journal that is dedicated to publishing research in all areas of applied technology in medicine and biomedical research. It is aimed at readers and authors with their main interest in the application of technology to solve problems in the medical and biological sciences, and overlapping areas of medicine and technology, such as (but not... read more

Published: 2017-06-26

Gastrointestinal Stromal Tumor Diagnosed During Donor Procurement: The Experience of a Single Institution and Review of the Literature

Luca Novelli, Luca Messerini, Chiara Caporalini, Lorenzo D’Antonio, Annarita Palomba, Camila Eva Comin

(Institute of Histopathology and Molecular Diagnosis, Careggi Hospital, Florence, Italy)

Med Sci Tech 2017; 58:62-66

DOI: 10.12659/MST.905005

BACKGROUND: Gastrointestinal stromal tumors (GISTs) are rare neoplasms accounting for 5% of all sarcomas, but they are the most common mesenchymal tumors within the gastrointestinal (GI) tract. GISTs occur throughout the GI tract, with the stomach being the most frequent site of origin.
MATERIAL AND METHODS: Herein, we describe 5 cases of GISTs diagnosed during donor procurement. Frozen sections of the tumors were highly suspicious for GISTs, and mitotic count evaluation was also performed. However, the definitive diagnosis and risk assessment required immunohistochemical staining for CD117 and DOG-1, together with the mitotic count performed on permanent sections.
RESULTS: From our 5 donors, 2 kidneys and 1 liver were transplanted with no evidence of donor-transmitted neoplasia after 18 and 46 months, respectively.
CONCLUSIONS: We describe 5 cases of GISTs with no risk of progressive disease. In accordance with the latest guidelines of the European Committee on Organ Transplantation, only donors with small gastric GIST were accepted for liver and renal transplant.

Keywords: gastrointestinal stromal tumors, Kidney Transplantation, Liver

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