Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

26 March 2021: Animal Study

Salvianic Acid A Regulates High-Glucose-Treated Endothelial Progenitor Cell Dysfunction via the AKT/Endothelial Nitric Oxide Synthase (eNOS) Pathway

Yanhua Guan 12ABCDEF , Xu Wang 13ABCDEF*

DOI: 10.12659/MSM.928153

Med Sci Monit 2021; 27:e928153

Figure 1 Identification of bone marrow-derived endothelial progenitor cells (EPCs) and effects of high glucose (HG) or different concentrations of salvianic acid A (SAA) on cell viability. (A) Morphology of EPCs derived from bone marrow. Scale bar=100 μm. (B) 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine-labeled acetylated low-density lipoprotein (Dil-ac-LDL) and fluorescein isothiocyanate-Ulex europaeus agglutinin-1 (FITC-UEA-1) double staining for identification of EPCs. Scale bar=50 μm. (C) 3-[4,5-Dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide (MTT) assay was performed to determine the effects of HG (30 mmol/L) on EPC viability at 1 day, 3 days and 7 days after culture. (Forty rats were used in this experiment.) ** P<0.01 compared to the control group.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750