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18 March 2021: Animal Study

Functional Dissection of CD26 and Its Pharmacological Inhibition by Sitagliptin During Skin Wound Healing

Yue Jiang 1BCD* , Yuan Yao 1BCF* , Jin Li 1AF , Yanling Wang 1CF , Jie Cheng 2DE , Yumin Zhu 1ADEG*

DOI: 10.12659/MSM.928933

Med Sci Monit 2021; 27:e928933

Figure 2 CD26 promotes cell proliferation, migration, and collagen biosynthesis in vitro. (A) Cell proliferation was remarkably increased in CD26+ WFs (CCK-8 viability assay). (B) The expressions levels of CD26 and Col1 were significantly increased in CD26+ WFs. Representative images of WB are shown. (C) The concentrations of CD26 and Col1 in the supernatant were determined by ELISA (n=5). * P<0.05 vs CD26+ NF group, ** P<0.01 vs CD26+ NF group. (D) Significant enhancement of cell migration in CD26+ WFs as gauged by wound healing assay and quantification (n=5). * P<0.05 vs CD26− NF group, ** P<0.01 vs CD26− WF group. (E) Significant enhancement of cell migration in CD26+ WFs as gauged by transwell assay and its quantification (n=5). ** P<0.01 vs CD26− NF/WF group. Scale bar: 100 μm, t test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750