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18 March 2021: Animal Study

Functional Dissection of CD26 and Its Pharmacological Inhibition by Sitagliptin During Skin Wound Healing

Yue Jiang 1BCD* , Yuan Yao 1BCF* , Jin Li 1AF , Yanling Wang 1CF , Jie Cheng 2DE , Yumin Zhu 1ADEG*

DOI: 10.12659/MSM.928933

Med Sci Monit 2021; 27:e928933

Figure 4 Pharmacological inhibition of CD26 inhibits collagen biosynthesis during skin wound healing and reduces scar formation. (A) Immunohistochemistry staining of CD26 in samples of normal skin, burn wounds, and wounds treated with sitagliptin. Scale bar: 100 μm. (B) Masson staining in samples of normal skin, burn wounds, and wounds treated with sitagliptin and its quantification (n=5). Scale bar: 200 μm. (C) The protein expressions levels of CD26 and Col1 in tissue samples following sitagliptin treatment were measured by western blot. Representative images are shown. (D) The mRNA expression levels of CD26 and Col1 were significantly decreased in samples of skin burn wounds following sitagliptin treatment (n=5). t test, * P<0.05 vs Normal group, ** P<0.01 vs Normal group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750