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25 March 2021: Clinical Research

Correlations of Silent Information Regulator of Transcription 1 (SIRT1) Expression, Inflammatory Factors, and Oxidative Stress with Pulmonary Function in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD)

Xin Zhao ACEG* , Yueqin Wu ABDF

DOI: 10.12659/MSM.929046

Med Sci Monit 2021; 27:e929046

Figure 4 Correlations of SIRT1 expression, IL-6 and IL-8 with FEV1 and FEV1/FVC in AECOPD patients. (A) Correlation between SIRT1 expression and FEV1 in the serum of AECOPD patients. A significant linear positive correlation was observed between SIRT1 activity and FEV1 in AECOPD patients (r2=0.75, P<0.001). (B) Correlation between SIRT1 expression and FEV1/FVC in the serum of AECOPD patients. A marked linear positive correlation was found between SIRT1 activity and FEV1/FVC in AECOPD patients (r2=0.74, P<0.001). (C) Relation between IL-6 and FEV1 in AECOPD patients. IL-6 had a remarkable linear negative relation with FEV1 in AECOPD patients (r2=0.83, P<0.001). (D) Relation between IL-6 and FEV1/FVC in AECOPD patients. IL-6 had a notable linear negative relation with FEV1/FVC in AECOPD patients (r2=0.81, P<0.001). (E) Association between IL-8 and FEV1 in AECOPD patients. There was an obvious linear negative association between IL-8 and FEV1 in AECOPD patients (r2=0.86, P<0.001). (F) Association between IL-8 and FEV1/FVC in AECOPD patients. There was an evident linear negative association between IL-8 and FEV1/FVC in AECOPD patients (r2=0.80, P<0.001).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750