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25 March 2021: Lab/In Vitro Research

Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells

Xiao Yang 1AC* , Dong Fang 2B* , Ming Li 1F , Jiayi Chen 1B , Yuanbo Cheng 1F , Jianming Luo 1DE*

DOI: 10.12659/MSM.929431

Med Sci Monit 2021; 27:e929431

Figure 3 Knockdown of CHI3L1 promotes cell apoptosis and cell survival-related proteins. (A) The effects of ShRNA- CHI3L1-1 on SU-DHL-4 cells apoptosis were measured by flow cytometry. (B) Western blot analysis of bax, cleaved caspase3, and cleaved PARP expression in SU-DHL-4. (C) Western blot analysis of p53 and survivin expression in SU-DHL-4. Data are presented as meanĀ±SD. Results shown here are the representative of 3 independent experiments. ** p<0.01, *** p<0.005 vs Control.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750