25 March 2021: Lab/In Vitro Research
Knockdown of Chitinase 3-Like-1 Inhibits Cell Proliferation, Promotes Apoptosis, and Enhances Effect of Anti-Programmed Death Ligand 1 (PD-L1) in Diffuse Large B Cell Lymphoma Cells
Xiao Yang 1AC* , Dong Fang 2B* , Ming Li 1F , Jiayi Chen 1B , Yuanbo Cheng 1F , Jianming Luo 1DE*DOI: 10.12659/MSM.929431
Med Sci Monit 2021; 27:e929431
Figure 4 knockdown of CHI3L1 promotes the effect of anti-PD-L1 antibody in the mouse model. (A–C) Representative images, growth, and weight of tumors following subcutaneous injection of the ShRNA-NC, ShRNA-CHI3L1-1, anti-PD-L1, anti-PD-L1+ ShRNA-CHI3L1-1, or control cells. (D, E) tumor volume and weight were measured at 3,5, 7, 9, 11, 13, and 15 days after injection of ShRNA-NC, ShRNA-CHI3L1-1, anti-PD-L1, anti-PD-L1+ ShRNA-CHI3L1-1, or control cells. Data are presented as mean±SD. Results shown here are the representative of 3 independent experiments. * p<0.05, ** p<0.01, *** p<0.005 vs Control; # p<0.05, ### p<0.005 vs shRNA-CHI3L1-1; @@ p<0.01, @@@ p<0.005 vs Anti-PD-L1.