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15 March 2021: Lab/In Vitro Research

Long Noncoding RNA TCONS_00068220 Promotes Breast Cancer Progression by Regulating Epithelial-Mesenchymal Transition Marker E-Cadherin

Xiao Liu 12ABEF , Xingsong Tian 1ACDG

DOI: 10.12659/MSM.929832

Med Sci Monit 2021; 27:e929832

Figure 6 TCONS_00068220 modulates breast cancer cell performance by downregulating E-cadherin. E-cadherin was overexpressed in pLVX-TCONS_00068220-transfected MCF-7 cells, while E-cadherin was silenced in MDA-MB-231 cells with TCONS_00068220 knockdown. (A) Assessment of the overexpression of E-cadherin by using qRT-PCR. (B) Cell viability was evaluated using the CCK8 assay. (C) Cell migration was measured by transwell assay. (D) Cell invasion was tested by Matrigel transwell assay. * P<0.05 vs negative control (NC) group; # P<0.05 vs pLVX-TCONS_00068220+pcDNA3.1-NC group or si-TCONS_00068220+si-NC.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750