Figure 1 Schematic diagram of construction the TESRUs: (A) First, autologous fibroblasts are loaded on a biodegradable macroporous microcarrier. (B) Second, autologous epidermal keratinocytes and melanocytes are incubated with the fibroblast-loaded microcarriers. (C) Autologous epidermal keratinocytes and autologous melanocytes are expanded in the fibroblast-loaded microcarriers, which are regarded as the smallest unit with complete full-thickness skin regeneration ability. (D) Multiple TESRUs are delivered to the wound surface to regenerate the full-thickness skin.