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04 December 2021: Clinical Research

A Pilot Randomized Controlled Trial of Intermittent Theta Burst Stimulation as Stand-Alone Treatment for Post-Stroke Aphasia: Effects on Language and Verbal Functional Magnetic Resonance Imaging (fMRI)

Jane B. Allendorfer 1BCDEF* , Rodolphe Nenert 1BCDE , Jennifer Vannest 2ABCDE , Jerzy P. Szaflarski 13ABCDEFG

DOI: 10.12659/MSM.934818

Med Sci Monit 2021; 27:e934818

Figure 3 Statistical maps illustrating fMRI activation changes during the verb-generation task (VGT; A–D) and verbal paired associates task (VPAT; E–F) and scatterplots showing Spearman correlations between changes in VPAT verbal encoding activation and change in aphasia quotient (AQ; H–I). Activation clusters are significant at corrected P<0.05. In the coronal (left image) and axial (middle image) slices, left in the image is left in the brain. Left in the sagittal slice (right image) is the anterior part of the brain. (A) At T1 compared to T2, Tx0 exhibited greater activation for speech production/auditory processing in the right and extending to the left visual cortex, and (B) for noun-verb semantic associations in the right and left visual cortex, right putamen and anterior insula, and bilateral cerebellum. (C) Tx123 exhibited greater activation for speech production/auditory processing in the right putamen, insula, superior medial gyrus and anterior cingulate cortex at T1 compared to T2, and (D) in the right inferior temporal gyrus at T3 compared to T2. (E) Activation for verbal encoding for Tx0 was greater at T2 relative to T1 in the right precuneus, middle cingulate cortex, paracentral lobule and postcentral gyrus. (F) Activation for verbal encoding for Tx123 was greater at T1 relative to T2 in the bilateral anterior cingulate cortex, and (G) greater at T3 relative to T1 in left visual regions (ie, fusiform gyrus extending to inferior/middle occipital gyrus). (H) There was a positive association between change from T1 to T3 in VPAT verbal encoding activation in left visual regions shown in G and corresponding change in AQ. (I) There was a negative association between change from T2 to T3 in verbal encoding activation in the a priori region of interest in the bilateral supplementary motor area (SMA) and change in AQ from T1 to T3.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750