29 September 2022>: Clinical Research
Postoperative Dynamic of Leptin and Fibroblast Growth Factor 21 in 123 Patients Recovering from Cardiac Surgery
Da Liu 1BCE , Danyal Ghani 2BCE , Wilson Y. Szeto 3ABE , Krzysztof Laudanski 456ABCDEFG*DOI: 10.12659/MSM.937652
Med Sci Monit 2022; 28:e937652
Figure 2 During the observation period, the dynamics of leptin and fibroblast growth factor 21 (FGF-21) as compared with inflammation markers, interleukin 6 (IL-6), C-reactive protein (CRP)(A) Leptin increased acutely at t24h (P<0.0001) to decline at t7d (P=0.043) while normalizing at t3m. (B) FGF-21 was elevated at both t24h (P<0.0001) and t7d (P<0.0001) and normalized at t3m. (C) Markers of acute inflammation, including IL-6 (D) were elevated at t24h (P<0.0001), while (E) CRP remained elevated across all of the time points (P<0.0001) as compared to baseline. Leptin levels slightly varied by surgery type at the baseline level and dynamics after surgery. Figures were generated using Prism by Graph Pad Dotmatics version 9. * Two-tailed significance less than 0.05 when data compared to baseline.