06 January 2004
Expression of TGFß1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin’s lymphomas
Dariusz Woszczyk, Joanna Gola, Magdalena Jurzak, Urszula Mazurek, Joanna Mykała-Cieśla, Tadeusz WilczokMed Sci Monit 2004; 10(1): CR33-37 :: ID: 11569
Abstract
Background:Transforming growth factor beta (TGFß) is involved in a variety of important cellular functions. The lack of TGFß-dependent cell-growth control might be related to oncogenesis, as it has been shown in lung, breast, and colon carcinomas. Current observations have revealed that TGFß is rather an inhibiting, not a stimulating, factor as far as malignant tumor development is concerned. Recently, however, there has been a growing number of reports on increased expression of TGFß genes in certain tumors. In patients with a diagnosis of non-small-cell lung carcinoma, the tumors expressing high levels of TGFß were the ones that had a higher proliferation and metastasis capability, whereas more promising were the cases with lower levels of TGFß expression.Material/Methods: A pilot study of 14 patients was conducted comprising 8 patients with a low-grade lymphoma and 6 patients with a high-grade lymphoma. The QRT-PCR method was employed to assess the activity of TGFß1 and of its receptor types I, II, and III.Results: The expression values for TGFß1 and its receptors I, II, and III were twice as high in the group of patients with a diagnosis of high-grade lymphomas as in the group of patients diagnosed with low-grade lymphomas.Conclusions: Results showed a clear difference in TGFß1 expression in patients with NHL depending on the subtype of the lymphoma, suggesting its significant role in the pathomechanism of this group of malignant diseases as well as its potential value as a prognostic factor.
Keywords: Activin Receptors, Type I - genetics, Base Sequence, DNA Primers - genetics, Lymphoma, High-Grade - genetics, Lymphoma, High-Grade - immunology, Lymphoma, Low-Grade - genetics, Lymphoma, Low-Grade - immunology, Pilot Projects, Proteoglycans - genetics, RNA, Messenger - genetics, RNA, Messenger - metabolism, Receptors, Transforming Growth Factor beta - genetics, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta - genetics, Transforming Growth Factor beta1, Activin Receptors, Type I - genetics, Base Sequence, DNA Primers - genetics, Lymphoma, Non-Hodgkin - immunology, Pilot Projects, Protein-Serine-Threonine Kinases, Proteoglycans - genetics, RNA, Messenger - metabolism, Receptors, Transforming Growth Factor beta - genetics, Reverse Transcriptase Polymerase Chain Reaction, Transforming Growth Factor beta - genetics, Transforming Growth Factor beta1
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952