Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

03 November 2003

The influence of glimepiride on the oxidative state of rats with streptozotocin-induced hyperglycemia

Hanna Krauss, Jacek Koźlik, Marian Grzymisławski, Przemysław Sosnowski, Kinga Mikrut, Jacek Piątek, Janusz Paluszak

Med Sci Monit 2003; 9(11): BR389-393 :: ID: 13276

Abstract

Background:The aim of this work was to determine whether glimepiride, a derivate of sulphonylurea of the hypoglycemic effect, influences the level of prooxidative factors and antioxidative enzymes activity in the course of experimental streptozotocin hyperglycemia in rats.Material/Methods:The studies were performed on healthy male Wistar rats of body weight 200±30 g, fed with the standard laboratory diet and given water ad libitum. Animals were divided into 3 groups, each consisting of 8 rats. Group I – control animals, Group II – animals in which experimental hyperglycemia was induced by intraperitoneal administration of streptozotocin (65 mg/kg body mass), Group III – animals which were given glimepiride orally for seven weeks (200 mg/kg of body mass), starting 24 hours after streptozotocin administration. Using Ohkawa method, malondialdehyde level was determined in plasma for all groups. Concentration of hydrogen peroxide was determined using method developed by Frew and co-workers, superoxide dismutase activity using the Misra and Fridovich method and activity of glutathione peroxidase by means of Ransel kit [Randox, Great Britain]. The decrease of glucose level in serum of rats under the influence of streptozotocin and glimepiride was observed when compared with the group given placebo.Results:Glimepiride administration caused a decrease of peroxides and malondialdehyde levels and increase in activity of superoxide dismutase and glutathione peroxidase in rats, after streptozotocin had been administered.Conclusions:The results suggest that glimepiride may effectively inhibit the development of the oxidative stress in diabetes.

Keywords: Antioxidants - pharmacology, Body Weight, Glutathione - metabolism, Hyperglycemia - chemically induced, Hypoglycemic Agents - pharmacology, Malondialdehyde - metabolism, Oxygen - metabolism, Peroxides - metabolism, Rats, Wistar, Streptozocin - pharmacology, Sulfonylurea Compounds - pharmacology

0 Comments

Editorial

01 December 2022 : Editorial  

Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939088

Med Sci Monit 2022; 28:e939088

SARS-CoV-2/COVID-19

29 November 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

24 November 2022 : Clinical Research  

A Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...

Med Sci Monit In Press; DOI: 10.12659/MSM.938665  

01 November 2022 : Clinical Research  

Questionnaire-Based Study of 81 Patients in Poland to Evaluate the Course of Inflammatory Bowel Disease and...

Med Sci Monit 2022; 28:e938243

In Press

05 Dec 2022 : Database Analysis  

Impact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Pe...

Med Sci Monit In Press; DOI: 10.12659/MSM.937737  

02 Dec 2022 : Clinical Research  

Value of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...

Med Sci Monit In Press; DOI: 10.12659/MSM.938637  

30 Nov 2022 : Clinical Research  

Retrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality in 170 Pati...

Med Sci Monit In Press; DOI: 10.12659/MSM.938674  

29 Nov 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750