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03 November 2003

Methylene blue: an effective treatment for contrast medium-induced anaphylaxis

Antonio M. Oliveira Neto, Neison M. Duarte, Walter V.A Vicente, Fernanda Viario, Paulo R.B. Evora

Med Sci Monit 2003; 9(11): CS102-106 :: ID: 13384

Abstract

Background:The purpose of this paper is to propose methylene blue as a lifesaving alternative drug for the treatment of contrast-induced anaphylaxis.Case Report:In a cardiovascular catheterization laboratory invasive hemodynamic monitoring was used to document the lifesaving effect of IV bolus injections of 1.5–2 mg/Kg methylene blue solution to treat three patients for anaphylactic shock following radiocontrast injection during coronary angiography. Methylene blue administration was followed by prompt circulatory improvement, leading to hemodynamic stabilization and relief of other anaphylactic symptoms in each case. There were no deaths.Conclusions:Our findings suggest that methylene blue can be lifesaving in anaphylactic shock, notwithstanding some transitory side effects, such as cardiac rhythm disturbances and chest pain, both of which possibly originate from sudden myocardial perfusion deficits.

Keywords: Contrast Media - adverse effects

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750