Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

02 May 2003

PARP-inhibitors for ischemia-reperfusion injury of the liver

H. Mota-Filipe

Med Sci Monit 2003; 9(1): 46- :: ID: 15109

Abstract

Ischemia-reperfusion (I/R) is responsible for the development of liver dysfunction and failure in several clinical conditions including liver transplantation and hemorrhagic shock. At the present, there is no pharmacological intervention proven to either attenuate liver cell injury or to augment tissue regeneration of the liver after acute or chronic injury of this organ. The occurrence of oxidant-mediated damage resulting from I/R has been demonstrated in several different animal models [1,2], where the generation of reactive oxygen species contributes to DNA damage [3]. One possible way of oxidant-induced injury involves the excessive activation of the nuclear enzyme poly-(ADP-ribose) polymerase (PARP).Using a rat model of liver I/R, we have the effects of the water-soluble PARP-inhibitor 5-aminoisoquinoline (5-AIQ) on liver injury (transaminases, histopathology), the upregulation of the adhesion molecule intracellular adhesion molecule 1 (ICAM-1) and the increase in PARP activity (measured as immunoreactivity of PAR), and the degree of lipid peroxidation caused by ischaemia and reperfusion (I/R) of the liver. When compared to control, 5-AIQ reduced the I/R-induced rise in the serum levels of transaminases, lactate dehydrogenase, and g-glutamyl transferase as well as the degree of lipid peroxidation. Liver sections obtained from 5-AIQ treated rats showed reduced PARP activation and less staining for ICAM-1. The role that PARP plays in the process of recovery that follows I/R injury to the liver will be discussed. References: 1.Caldwell-Kendel JC, Currin RT, Tanaka Y et al: Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology, 1989; 10: 92-9 2.Schoenberg MH, Muhl E, Sellin D et al: Posthypotensive generation of superoxide free-radicals – possible role in the pathogenesis of the intestinal mucosal damage. Acta Chir Scand, 1984; 150: 301-9 3.Martin D, Lewington A, Hammerman M, Padanilam B: Inhibition of poly (ADP-ribose) polymerase attenuates ischemic renal injury in rats. Am J Physiol Regulatiry Integrative Comp Physiol, 2000; 279: 1834-40

Keywords: Liver, ischemia-reperfusion, PARP, 5-aminoisoquinoline

0 Comments

Editorial

01 December 2022 : Editorial  

Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939088

Med Sci Monit 2022; 28:e939088

SARS-CoV-2/COVID-19

29 November 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

24 November 2022 : Clinical Research  

A Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...

Med Sci Monit In Press; DOI: 10.12659/MSM.938665  

01 November 2022 : Clinical Research  

Questionnaire-Based Study of 81 Patients in Poland to Evaluate the Course of Inflammatory Bowel Disease and...

Med Sci Monit 2022; 28:e938243

In Press

02 Dec 2022 : Clinical Research  

Value of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...

Med Sci Monit In Press; DOI: 10.12659/MSM.938637  

30 Nov 2022 : Clinical Research  

Retrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality in 170 Pati...

Med Sci Monit In Press; DOI: 10.12659/MSM.938674  

29 Nov 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

28 Nov 2022 : Review article  

A Review of the Roles of Apelin and ELABELA Peptide Ligands in Cardiovascular Disease, Including Heart Fail...

Med Sci Monit In Press; DOI: 10.12659/MSM.938112  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750