Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 August 2005

Endocannabinoid Signaling in Stress, Medicine and Wellness

Tobias Esch

Med Sci Monit 2005; 11(8): ED3-5 :: ID: 199607

Abstract

Based on self-care and stress research, it is reasonable to propose thatour bodies contain naturally occurring properties, that is, tools that serve to maintain our health andintegrity for a passable period of time, even in times of stress: These processes, including endocannabinoidautoregulation, might in part determine our well-being and life span. Such properties would also manifestthemselves during times of stress, i.e, stress reduction. Stress potentially triggers endocannabinoidand NO synthesis and release. In fact, endocannabinoids exert stress-reducing functions by their potentialto modulate norepinephrine release, e.g., via constitutive NO activation, therefore suggesting a sympatho-inhibitorymechanism that effectively diminishes sympathetic tone. This stress-reducing and health-promoting potentialcan be detected not only in central but also peripheral pathways, again indicating general or systemicdown-regulation. In this process, signaling molecules such as the endocannabinoids may play a role inconnecting mind and body phenomena, and one could speculate that such evolutionarily old autoregulatorypathways, by using endocannabinoids as one type of their molecular messengers and constitutive NO asa possible converging point, are involved in natural or innate health promotion, including wellness,reward and pleasure. Consequently, endocannabinoid research has now become a focus not only of neurobiologicalbut also medical science: With this interdisciplinary approach, we will gather new insight on these fascinatingmolecules and their healing properties in the coming years ahead.

Keywords: Endocannabinoids - metabolism, Health, Medicine, Stress - metabolism, Cannabinoid Receptor Modulators - metabolism, Endocannabinoids, Health, Medicine, Stress, Physiological - metabolism

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750