01 January 2001
CD52 antigen--a review.
Alina Domagała, Maciej KurpiszMed Sci Monit 2001; 7(2): RA325-331 :: ID: 421140
Abstract
Human CD52 is a glycosylphosphatidylinositol (GPI)--anchored antigen expressedon the all lymphocytes as well as within the male genital tract, where it can be produced by epithelialcells of the distal epididymis and duct deferens. CD52 can be shed into seminal plasma and then acquiredby sperm cells during their passage through the genital tract, thus it is detectable on the surface ofepididymal sperm and in the ejaculate but not on either spermatogenetic cells or testicular spermatozoa.Protein core of the sperm and lymphocyte CD52 is identical and it is a product of a single copy genelocated on chromosome 1. However, N-linked carbohydrate side chains (attached to Asn-3) and GPI-anchorstructure are different. Physiological role of CD52 on lymphocytes is unclear, although antibody directedto CD52, CAMPATH-1, is capable of complement activation and it can be clinically useful to treat lympho-proliferativedisorders and to deplete lymphocytes in bone marrow transplants. Monoclonal antibodies directed againstsperm CD52 may cause sperm immobilisation and agglutination and affect hamster oocyte penetration suggestingan association of this molecule with fertilisation.
Keywords: Glycocalyx, Antigens, sperm glycoproteins, CD52
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952