01 September 2005
Activities of red blood cell anti-oxidative enzymes (SOD, GPx) and total anti-oxidativecapacity of serum (TAS) in men with coronary atherosclerosis and in healthy pilots.
Ewelina Zawadzka-BartczakMed Sci Monit 2005; 11(9): CR440-444 :: ID: 428453
Abstract
Background: Reactive oxygen species (ROS) have been proposed to play importantpathogenic roles, especially in harmful oxidative modifications of low-density cholesterol. Redox balancewithin the organism is largely determined by the activities of anti-oxidative enzymes of red blood cellsand by the total anti-oxidative capacity of the serum (TAS). Material/Methods: SOD and GPx activitiesand TAS in 13 men aged 42-65 years with coronary atherosclerosis (group I) were compared with those ofboth 15 clinically healthy pilots matched for age and lipid abnormalities (cholesterol and triglycerides)(group II) and 14 age-matched pilots without lipid abnormalities (group III). Results: There were statisticallysignificant differences in SOD and GPx activities and in TAS between the groups. Conclusions: 1. SODand GPx activities and TAS were lower in men with advanced coronary atherosclerosis that in age-matchedclinically healthy men with similar dyslipidemia and were even further decreased compared with clinicallyhealthy men without dyslipidemia. 2. The decrease in SOD and GPx activities and TAS in men with advancedcoronary atherosclerosis was more pronounced than the degree of hypercholesterolemia or hypertriglyceridemia.3. If hyperlipidemia and the activity of antioxidative enzymes and TAS were considered without referenceto other risk factors of atherosclerosis, it appeared that the decreases in SOD, GPx, and TAS may playa more important role in the development of the atherosclerotic process than isolated increases in freecholesterol or triglyceride levels.
Keywords: Aerospace Medicine, Antioxidants - metabolism, Case-Control Studies, Cholesterol - blood, Coronary Artery Disease - enzymology, Erythrocytes - enzymology, Glutathione Peroxidase - blood, Reactive Oxygen Species - blood, Superoxide Dismutase - blood, Triglycerides - blood
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952