01 October 2003
The influence of anesthesia with nitrous oxide for laparoscopic cholecystectomy on whole blood chemiluminescenceWojciech Krajewski, Andrzej Wieczorek, Dariusz Nowak, Maria Łuczyńska, Magdalena Solecka, Agata Sarniak
Med Sci Monit 2003; 9(5): 44-47 :: ID: 428730
Operation is always connected with trauma and inflamation,humoral and metabolic response.Neutrophils are the basic component of the immunological system.One of the methods allowing to dynamically assess whole blood neutrophil activity is chemiluminescence assay.The aim of this study is assessment of the influence of general anesthesia for laparoscopic cholecystectomy on whole blood chemi- luminescence.Thirty two patients were enrolled into the study (11 men,21 women),aged 26 –69 years (average 53.1 years).Anaesthesia was induced by propofol (2 mg/kg b.w.),muscle relaxation achieved with atracurium (0.5 mg/kg b.w.).Tracheal intubation was performed, maintenance included nitrous oxide (66%)in oxygen,fentanyl (5 µg/kg b.w./hour)and atracurium (0.6 mg/kg b.w./hour). Blood samples were collected: immediately before the anesthesia induction (T 1 ),one hour after induction (T 2 )and 5 minutes after extubation (T 3 ).The basal (bCl)and fMLP-induced whole blood chemiluminescence was measured according to Kukovetz at al. Statistical analysis of obtained data was performed with Shapiro-Wilk, U Mann-Whitney and Friedman tests. No significant changes both in basic chemiluminescence and after stimulation (calculation made for 10 4 neutrophils)were found,which shows that there is no increase in neutrophil activity during the anesthesia and surgery.
Keywords: anasthesia, Nitric Oxide, Free Radicals, Neutrophils, chemiluminescence, Laparoscopic cholecystectomy
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic
Med Sci Monit 2022; 28:e939088
29 November 2022 : Clinical ResearchRetrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...
Med Sci Monit In Press; DOI: 10.12659/MSM.938647
24 November 2022 : Clinical ResearchA Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...
Med Sci Monit In Press; DOI: 10.12659/MSM.938665
01 December 2022 : EditorialEditorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Funga...
Med Sci Monit 2022; 28:e939088
05 Dec 2022 : Database AnalysisImpact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Pe...
Med Sci Monit In Press; DOI: 10.12659/MSM.937737
02 Dec 2022 : Clinical ResearchValue of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...
Med Sci Monit In Press; DOI: 10.12659/MSM.938637
30 Nov 2022 : Clinical ResearchRetrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality in 170 Pati...
Med Sci Monit In Press; DOI: 10.12659/MSM.938674
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996