01 October 2003
The influence of anesthesia with nitrous oxide for laparoscopic cholecystectomy on whole blood chemiluminescenceWojciech Krajewski, Andrzej Wieczorek, Dariusz Nowak, Maria Łuczyńska, Magdalena Solecka, Agata Sarniak
Med Sci Monit 2003; 9(5): 44-47 :: ID: 428730
Operation is always connected with trauma and inflamation,humoral and metabolic response.Neutrophils are the basic component of the immunological system.One of the methods allowing to dynamically assess whole blood neutrophil activity is chemiluminescence assay.The aim of this study is assessment of the influence of general anesthesia for laparoscopic cholecystectomy on whole blood chemi- luminescence.Thirty two patients were enrolled into the study (11 men,21 women),aged 26 –69 years (average 53.1 years).Anaesthesia was induced by propofol (2 mg/kg b.w.),muscle relaxation achieved with atracurium (0.5 mg/kg b.w.).Tracheal intubation was performed, maintenance included nitrous oxide (66%)in oxygen,fentanyl (5 µg/kg b.w./hour)and atracurium (0.6 mg/kg b.w./hour). Blood samples were collected: immediately before the anesthesia induction (T 1 ),one hour after induction (T 2 )and 5 minutes after extubation (T 3 ).The basal (bCl)and fMLP-induced whole blood chemiluminescence was measured according to Kukovetz at al. Statistical analysis of obtained data was performed with Shapiro-Wilk, U Mann-Whitney and Friedman tests. No significant changes both in basic chemiluminescence and after stimulation (calculation made for 10 4 neutrophils)were found,which shows that there is no increase in neutrophil activity during the anesthesia and surgery.
Keywords: anasthesia, Nitric Oxide, Free Radicals, Neutrophils, chemiluminescence, Laparoscopic cholecystectomy
01 March 2023 : EditorialEditorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza Pandemic
Med Sci Monit 2023; 29:e939968
03 March 2023 : Database AnalysisReinfections from SARS-CoV-2: A Retrospective Study from the Gyncentrum Genetic Laboratory in Sosnowiec, Po...
Med Sci Monit In Press; DOI: 10.12659/MSM.939452
09 February 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical ResearchEffect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...
Med Sci Monit 2022; 28:e938926
22 Mar 2023 : Special reportOne Year On: Poland’s Public Health Initiatives and National Response to Millions of Refugees from Ukraine
Med Sci Monit In Press; DOI: 10.12659/MSM.940223
22 Mar 2023 : Clinical ResearchValue of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective Study
Med Sci Monit In Press; DOI: 10.12659/MSM.940163
21 Mar 2023 : Clinical ResearchEfficacy of Direct Anterior Approach Versus Posterior Lateral Approach for Total Hip Replacement in Patient...
Med Sci Monit In Press; DOI: 10.12659/MSM.939682
21 Mar 2023 : Clinical ResearchIntraoperative Hypotension and Its Association with Postoperative Acute Kidney Injury in Patients Undergoin...
Med Sci Monit In Press; DOI: 10.12659/MSM.938945
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...
Med Sci Monit 2022; 28:e935952