Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 2005

Apoptosis in liver diseases - detection and therapeutic applications.

Saeid Ghavami, Saeid Ghavami, Mohammad Hashemi, Kamran Kadkhoda, Seyed Moayed Alavian, Graham H Bay, Marek Los

Med Sci Monit 2005; 11(11): RA337-345 :: ID: 430372


The liver is continuously exposed to a large antigenic load that includespathogens, toxins, tumor cells and dietary antigens. Amongst the hepatitis viruses, only hepatitis Bvirus (HBV) and hepatitis C virus (HCV) cause chronic hepatitis, which can progress to cirrhosis andhepatocellular carcinoma. Of the different antiviral defense systems employed by the tissue, apoptosissignificantly contributes to the prevention of viral replication, dissemination, and persistence. Lossof tolerance to the liver autoantigens may result in autoimmune hepatitis (AIH). This review outlinesthe recent findings that highlight the role and mechanisms of apoptotic processes in the course of liverdiseases. Among factors that contribute to liver pathology, we discuss the role of tumor necrosis factor(TNF)-alpha, HBx, ds-PKR, TRAIL, FasL, and IL-1alpha. Since TNF and FasL-induced hepatocyte apoptosisis implicated in a wide range of liver diseases, including viral hepatitis, alcoholic hepatitis, ischemia/reperfusionliver injury, and fulminant hepatic failure, these items will be discussed in greater detail in thisreview. We also highlight some recent discoveries that pave the way for the development of new therapeuticstrategies by protecting hepatocytes (for example by employing Bcl-2, Bcl-X(L) or A1/Bfl-1, IAPs, orsynthetic caspase inhibitors), or by the induction of apoptosis in stellate cells. The assessment ofthe severity of liver disease, as well as monitoring of patients with chronic liver disease, remainsa major challenge in clinical hepatology practice. Therefore, a separate chapter is devoted to a novelcytochrome c - based method useful for the diagnosis and monitoring of fulminant hepatitis.

Keywords: Biological Markers - analysis, Autoimmune Diseases - metabolism, Cytochromes c - analysis, Liver Diseases - therapy, Tumor Necrosis Factors - physiology



01 December 2022 : Editorial  

Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939088

Med Sci Monit 2022; 28:e939088


29 November 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

24 November 2022 : Clinical Research  

A Prospective Questionnaire-Based Study to Evaluate Factors Affecting the Decision to Receive COVID-19 Vacc...

Med Sci Monit In Press; DOI: 10.12659/MSM.938665  

01 November 2022 : Clinical Research  

Questionnaire-Based Study of 81 Patients in Poland to Evaluate the Course of Inflammatory Bowel Disease and...

Med Sci Monit 2022; 28:e938243

In Press

05 Dec 2022 : Database Analysis  

Impact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Pe...

Med Sci Monit In Press; DOI: 10.12659/MSM.937737  

02 Dec 2022 : Clinical Research  

Value of Early Laparoscopic Exploration for Primary Infertile Patients with Patent Fallopian Tubes Complica...

Med Sci Monit In Press; DOI: 10.12659/MSM.938637  

30 Nov 2022 : Clinical Research  

Retrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality in 170 Pati...

Med Sci Monit In Press; DOI: 10.12659/MSM.938674  

29 Nov 2022 : Clinical Research  

Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...

Med Sci Monit In Press; DOI: 10.12659/MSM.938647  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750