22 December 2005
Study of insulin-like growth factor-1 (IGF-1) and platelet-derived endothelialcell growth factor (PDEGF) expression in children with infantile hypertrophic pyloric stenosis.
Janusz Jabłoński, Renata Gawrońska, Aleksandra Gawłowska, Józef Kobos, Ewa AndrzejewskaMed Sci Monit 2006; 12(1): CR27-30 :: ID: 443187
Abstract
Background: The pathogenesis of infantile hypertrophic pyloric stenosis(IHPS) is not fully understood. Hypertrophy of the pyloric muscle is probably regulated by growth factors.Recent studies reported an increase in the local synthesis of insulin-like growth factor-1 (IGF-1). Thereare no reports concerning platelet-derived endothelial cell growth factor (PDEGF) playing an importantrole in the pathological angiogenesis. The aim of this study was to analyze the expressions of IGF-1and PDEGF by immunohistochemistry (IHC) in the muscularis propria of the pyloric muscle in children withIHPS. Material/Methods: Twenty-two muscle biopsies were obtained at the time of pyloromyotomy. The controlgroup consisted of seven children. Specimens were evaluated by routine histopathological methods andby immunohistochemistry using monoclonal mouse anti-PDEGF or -IGF-1 antibodies. Cells showing positivereaction were counted in five random 200x high-power fields. Values were expressed as the mean +/-SDof the real expression area of the analyzed marker to the total analyzed area. Results: In children withIHPS the average area of PDEGF expression was 62+/-52.5, whereas in the control group it was 15+/-12.1.The average area of IGF-1 expression was 1037+/-491.9) in study group and 259+/-221.44 in the controls.Statistically significant differences were found. Conclusions: These results show a local increase inthe expressions of IGF-1 and PDEGF in the muscularis propria of the pyloric muscle in children with IHPS,which may have implications to the pathogenesis of the disease.
Keywords: Biopsy, Child, Insulin-Like Growth Factor I - metabolism, Pyloric Stenosis, Hypertrophic - surgery, Pylorus - surgery, Random Allocation, Thymidine Phosphorylase - metabolism
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952