Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 March 2006

Can an increased level of circulating IL-8 be a predictor of human longevity?

Katarzyna Wieczorowska-Tobis, Zofia I. Niemir, Renata Podkówka, Katarzyna Korybalska, Małgorzata Mossakowska, Andrzej Bręborowicz

Med Sci Monit 2006; 12(3): CR118-121 :: ID: 447109

Abstract

BACKGROUND: Interleukin-6 (IL-6) and IL-8 are considered to be potent inflammatory agents. However, IL-8 has also been reported to serve as an organ protective factor. The goal of our study was to compare the circulating levels of IL-8 and IL-6 in C-reactive protein (CRP)-negative subjects of different ages. MATERIAL/METHODS: Seventy subjects living in the Wielkopolska region were enrolled into the study and divided into three groups: group 1-30 young healthy subjects 21-37 years of age; group 2-30 healthy elderly individuals, age 65-87; group 3-10 centenarians (100-105 years). In all of these subjects, serum levels of IL-6 and IL-8 were assessed with an enzyme-linked immunosorbent assay. RESULTS: Concerning IL-6, both the serum concentration and the frequency of results above the sensitivity limit were comparable in all groups. With respect to IL-8, the frequency of results beyond the sensitivity limit in groups 1 and 2 did not differ significantly (5/30 and 8/30, respectively). By contrast, the majority of subjects from group 3 had an IL-8 level above the limit (9 out of 10; p

Keywords: Aged, 80 and over, C-Reactive Protein - analysis, Enzyme-Linked Immunosorbent Assay, Interleukin-6 - blood, Interleukin-8 - blood, Longevity, Predictive Value of Tests, Reference Standards, Sensitivity and Specificity

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

26 Feb 2024 : Clinical Research  

Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...

Med Sci Monit In Press; DOI: 10.12659/MSM.942509  

Most Viewed Current Articles

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750