Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

28 January 2003

Experimental studies of serum cytokine concentration following pancreatic electrolytic ablation.

Charles P. Morrison, Benjamin D. Teague, Fiona G. Court, Simon A. Wemyss-Holden, Mathew S. Metcalfe, Ashley R. Dennison, Guy J. Maddern

Med Sci Monit 2003; 9(1): BR43-46 :: ID: 4785

Abstract

BACKGROUND: Pancreatic cancer has a poor prognosis, with symptomatic palliation being the priority in the majority of cases. Alternative palliative techniques, such as local ablation, are under investigation. Palliative per-ductal electrolytic ablation of the pancreas has been reported, in an experimental series. It is important to establish that this technique is associated with low morbidity and mortality if it is to be acceptable. The 'systemic inflammatory response syndrome' (SIRS) is a recognised and serious complication of both acute pancreatitis, and certain locally ablative techniques. This study aimed to determine whether pancreatic electrolytic ablation is associated with an increase in serum IL-1ß and TNF-α concentrations, these cytokines playing integral roles in the inflammatory pathway of SIRS. MATERIAL/METHODS: Eight pigs underwent per-ductal electrolytic ablation of the pancreas. Serum samples, taken pre-operatively and post-operatively for two weeks, were analysed for IL-1ß and TNF-α concentrations. Variations in cytokine levels were statistically analysed. RESULTS: Post-operative serum IL-1ß and TNF-α concentrations did not significantly increase on pre-operative figures. There were no other clinical, biochemical or histological indicators of a SIRS-like phenomenon. CONCLUSIONS: The results from this study suggest that electrolytic ablation of normal pancreas is not associated with either an increase in serum concentrations of IL-1ß and TNF-α or a SIRS phenomenon. Although this study has only investigated the serum levels of two cytokines, IL-1ß and TNF-α have both been shown to have a central role in the inflammatory cascade that leads to SIRS.

Keywords: Catheter Ablation - methods, Cytokines - blood, Interleukin-1 - blood, Pancreas - pathology, Swine, Time Factors, Tumor Necrosis Factor-alpha - biosynthesis

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750