18 May 2007
Analysis of correlation between the degree of cognitive impairment and the results of perfusion CT in patients with dementia
Anna Zimny, Jerzy Leszek, Andrzej Kiejna, Marek SąsiadekMed Sci Monit 2007; 13(1): 23-30 :: ID: 482278
Abstract
Background: The aim of the study was to assess the relationship between cognitive impairment according to the Mini Mental State Examination (MMSE) and values of cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) obtained in perfusion CT (pCT). Material and Methods: Sixty-four patients with dementia (36 with Alzheimer’s disease, 15 with vascular dementia, and 13 with mixed dementia), aged 45–92 years (mean: 69.9 years) with different degrees of cognitive impairment (mean MMSE score: 17.0) were involved in the study. All subjects underwent pCT at the level of the basal ganglia (50 scans, 1 scan/s, 40 ml contrast medium at 4 ml/s, delay: 7 s). CBF, CBV, and MTT values from 31 regions of interest (ROIs) in the gray and white matter of the frontal and temporal lobes, lentiform nuclei, and internal capsules were correlated with the MMSE scores.
Results: Statistical analysis of CBF and MMSE revealed significant correlations in 22/31 ROIs including the gray and white matter of the frontal and temporal lobes, both internal capsules, right and left hemispheres, and total gray and white matter. Analysis of CBV and MMSE showed significant correlations in 21/31 ROIs in the gray and white matter of the frontal and temporal lobes, both internal capsules, left lentiform nucleus, right and left hemispheres, as well as total gray matter. There were no significant correlations between MTT and MMSE. Conclusions: CBF and CBV calculated with pCT correlate with cognitive impairment in patients with dementia and thus may play a role in monitoring disease progression or therapeutic response.
Keywords: Aged, 80 and over, Brain - physiology, Cerebrovascular Circulation - physiology, Cognition Disorders - radiography, Dementia - radiography, Neuropsychological Tests, Regional Blood Flow, Statistics as Topic, Tomography, X-Ray Computed
Editorial
01 March 2023 : Editorial
Editorial: Global Surveillance of Highly Pathogenic Avian Influenza Viruses in Poultry, Wild Birds, and Mammals to Prevent a Human Influenza PandemicDOI: 10.12659/MSM.939968
Med Sci Monit 2023; 29:e939968
SARS-CoV-2/COVID-19
09 February 2023 : Clinical Research
Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...Med Sci Monit 2023; 29:e938892
19 January 2023 : Clinical Research
Determining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...Med Sci Monit 2023; 29:e939238
27 December 2022 : Clinical Research
Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...Med Sci Monit 2022; 28:e938926
10 December 2022 : Clinical Research
Retrospective Study to Identify Risk Factors for Severe Disease and Mortality Using the Modified Early Warn...Med Sci Monit 2022; 28:e938647
In Press
24 Mar 2023 : Database Analysis
Causes of Death Following Gastric Cancer Diagnosis: A Population-Based AnalysisMed Sci Monit In Press; DOI: 10.12659/MSM.939848
22 Mar 2023 : Special report
One Year On: Poland’s Public Health Initiatives and National Response to Millions of Refugees from UkraineMed Sci Monit In Press; DOI: 10.12659/MSM.940223
22 Mar 2023 : Clinical Research
Value of IL-1β and IL-23 in Predicting 28-Day Mortality Due to Sepsis: A Retrospective StudyMed Sci Monit In Press; DOI: 10.12659/MSM.940163
21 Mar 2023 : Clinical Research
Efficacy of Direct Anterior Approach Versus Posterior Lateral Approach for Total Hip Replacement in Patient...Med Sci Monit In Press; DOI: 10.12659/MSM.939682
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952