Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

18 May 2007

Magnetic Resonance evaluation of disease activity in Graves' ophthalmopathy: T2-time and signal intensity of extraocular muscles.

Agata Majos, Michał Pająk, Marcin Elgalal, Piotr Grzelak, Ludomir Stefańczyk

Med Sci Monit 2007; 13(1): 44-48 :: ID: 482354

Abstract

Background: It is accepted that T2-weighted imaging can demonstrate the extent of an inflammatory process in Graves' ophthalmopathy (GO). This aim of this study was a comparative evaluation of the most commonly used indicators of extraocular muscle pathophysiology, i.e. signal intensity (SI) and T2-time (T2-t) in correlation with muscle volume (MV), and to determine the need to make the above indicators objective with regards to clinical practice. Material/Methods: MRI examinations in a 1.5 T scanner of 40 orbits formed the study group. Quantitative assessment of the muscles was carried out using a numerical segmentation imaging technique (NSI). SI and T2-t were measured for each muscle. A standardization algorithm was applied based on T2-t and IS from the ipsilateral white matter of the frontal lobes. Results: The correlation between T2-t and MV for the medial rectus and inferior rectus muscles (IRM) was at a comparatively high level (R: 0.49 and 0.47), with a value as high as R=0.58 for the superior rectus muscle. Correlation between SI and volume for these muscles was found to be at R-levels of 0.37, 0.48, and 0.46. Correction of the T2-t and SI values with use of a standardization algorithm in most cases did not change the above correlations, except for IRM. Conclusions: The parameter with the higher correlation to the symptoms of GO is T2 The value of SI as an indicator of disease intensity in GO that can be used without the use of multiple echo sequences was confirmed. It is necessary to make the above parameters objective relative to white matter when calculating IS for the inferior rectus muscle.

Keywords: Disease Progression, Graves Ophthalmopathy - physiopathology, Magnetic Resonance Imaging, Oculomotor Muscles - physiopathology, Statistics as Topic

0 Comments

Editorial

01 August 2022 : Editorial  

Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937927

Med Sci Monit 2022; 28:e937927

In Press

05 Aug 2022 : Clinical Research  

A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...

Med Sci Monit In Press; DOI: 10.12659/MSM.936923  

05 Aug 2022 : Clinical Research  

Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...

Med Sci Monit In Press; DOI: 10.12659/MSM.937146  

04 Aug 2022 : Clinical Research  

Radiological Assessment of Prevalance and Quality of Periapical Status of Endodontic Treatments

Med Sci Monit In Press; DOI: 10.12659/MSM.936569  

01 Aug 2022 : Clinical Research  

Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical...

Med Sci Monit In Press; DOI: 10.12659/MSM.936637  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750