01 July 2007
Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests
Dinesh Dhingra, Rekha ValechaMed Sci Monit 2007; 13(7): BR155-161 :: ID: 487343
Abstract
Background:
This study investigates the effect of the petroleum ether, chloroform, and ethyl acetate fractions of the total ethanolic extract of Convolvulus pluricaulis Choisy (Family: Convolvulaceae) on depression in mice.
Material/Methods:
The petroleum ether (25, 50 mg/kg), chloroform (25, 50, 100 mg/kg), and ethyl acetate (25, 50, 100 mg/kg) fractions were administered orally for 10 successive days to separate groups of Swiss young male albino mice. The effects of the extracts on the mice’s immobility periods were assessed in the forced swim test (FST) and tail suspension test (TST). The effects of reserpine (2 mg/kg i.p.), sulpiride (50 mg/kg i.p.), prazosin (62.5 µg/kg i.p.), and p-chlorophenylalanine (100 mg/kg i.p.) on the extracts’ antidepressant-like effect in TST was also studied. The extracts’ antidepressant-like effect was compared with that of imipramine (15 mg/kg p.o.) and fluoxetine (20 mg/kg p.o.) administered for 10 successive days.
Results:
Only the chloroform fraction in doses of 50 and 100 mg/kg significantly reduced the immobility time in both FST and TST. This fraction did not significant effect locomotor activity. Its efficacy was found to be comparable to that of imipramine and fluoxetine administered for 10 successive days. The chloroform fraction reversed reserpine-induced extension of immobility period in FST and TST. Prazosin, sulpiride, and p-chlorophenylalanine significantly attenuated the chloroform fraction-induced antidepressant-like effect in TST.
Conclusions:
The chloroform fraction of the total ethanolic extract of Convolvulus pluricaulis elicited a significant antidepressant-like effect in mice by interaction with the adrenergic, dopaminergic, and serotonergic systems.
Keywords: Alkanes - chemistry, Acetates - chemistry, Antidepressive Agents - pharmacology, Chloroform - chemistry, Convolvulus - metabolism, Depression - drug therapy, Fenclonine - chemistry, Hindlimb Suspension, Motor Activity - drug effects, Plant Extracts - pharmacology, Prazosin - chemistry, Reserpine - pharmacology, Sulpiride - chemistry
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
05 Mar 2024 : Clinical Research
Role of Critical Shoulder Angle in Degenerative Type Rotator Cuff Tears: A Turkish Cohort StudyMed Sci Monit In Press; DOI: 10.12659/MSM.943703
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952