01 May 1996
Selected elements of the pathogenesis of pruritus in haemodialysis patients the own study
Jacek SzepietowskiMed Sci Monit 1996; 2(3): HY343-347 :: ID: 499885
Abstract
Etiopathogenesis of uraemic pruritus remains unclear. In the present study, including 119 chronic haemodialysis patients, the correlation between pruritus and methods of haemodialysis and associated metabolic abnormalities was evaluated. In addition in 32 patients cutaneous mast cells were studied using enzymocytochemical methods. Pruritus was found in 58.8% of the patients. In the pruritic haemodialysis patients serum calcium concentrations were significantly increased. Moreover, serum phosphorus concentrations were also evidently elevated in the patients with pruritus. Pruritus was found to be more common in patients with a longer haemodialysis period and in patients haemodialysed using less permeable cuprophane dialyzers compared to those dialysed using polysulphone dialyzers. No correlation was demonstrated between the frequency and intensity of pruritus and the type of dialysate, erythropoietin intake, age and sex of patients, underlying renal disease, degree of anaemia and serum concentrations of urea, creatinine, sodium, potassium, magnesium, parathormone and alkaline phosphatase. In the haemodialysis patients the mean number of cutaneous mast cells was significantly higher compared to healthy individuals. No correlation was found with the number of mast cells and duration of haemodialysis period, the serum concentrations of calcium, phosphorus, magnesium and parathormone. In the pruritic patients mast cells were only slightly more numerous than in nonpruritic subjects, although in the patients suffering from pruritus the percentage of tryptase-positive chymase-positive mast cells was significantly decreased compared to nonpruritic individuals. This can play an important role in the etiopathogenesis of pruritus in patients on maintenance haemodialysis treatment.
Keywords: uremic pruritus, haemodialysis, Mast Cells
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952