03 March 1997
Early side effects on normal tissue of radiotherapy for head and neck cancers correlation with activities of free radical scavenging enzymesDorota Tarnawska, Krzysztof Składowski, Wojciech Jacheć, Roman Tarnawski, Andrzej Tomasik, Bogusław Maciejewski
Med Sci Monit 1997; 3(2): CR199-203 :: ID: 500692
Early side effects of radiation therapy seem to be a major limiting factor in treatment intensification for head and neck cancers. Correlations between the activity of Cu,Zn-superoxide dismutase (SOD), gluthatione peroxidase (GPX), gluthatione transferase (GST); the concentration of malonyldialdehyde (MDA), 7-ketocholesterol, and the severity of early mucosal radiation damage were studied in 90 patients treated with radical radiotherapy. Mucosal reactions were scored according to the Dische scale. Enzymatic activities were studied in erythrocytes, and concentrations of lipid oxidation were measured in blood plasma. The mean Cu,Zn-SOD activity before treatment was 947 U/g Hb, mean GPX activity 21 U/g Hb, MDA concentration in plasma 4.2 µg/l, MDA concentration in erythrocytes 0.19 µg/g Hb, and 7-ketocholesterol concentration 228 µg/l. Only gluthatione peroxidase (r=0.54) and gluthatione peroxidase/superoxide dismutase activity ratio (r=0.52) correlated with the severity of clinically observed early radiation damage. As a wide spectrum of the enzymatic activities was observed for the same level of normal tissue injury, it is not possible to predict the clinical radiosensitivity of individual patients from the estimation of the free radical enzymatic scavenging activity.
Keywords: radiation injury, Radiotherapy, gluthatione peroxidase, oxygen free radicals, Dose Fractionation
01 October 2023 : EditorialEditorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution
Med Sci Monit 2023; 29:e942672
02 Oct 2023 : Clinical ResearchComparison of Nanocrystalline Hydroxyapatite Bone Graft with Empty Defects in Long Bone Fractures: A Retros...
Med Sci Monit In Press; DOI: 10.12659/MSM.941112
02 Oct 2023 : Review articleCircadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities
Med Sci Monit In Press; DOI: 10.12659/MSM.942215
30 Sep 2023 : Clinical ResearchInfluence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Pat...
Med Sci Monit In Press; DOI: 10.12659/MSM.940128
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292