01 July 1997
Effects of selected metalloporphyrins on the proliferation of human colorectal carcinoma
Petr Pohlreich, Jana Stribrna, Jaromr Kremen, Pavel MartasekMed Sci Monit 1997; 3(4): BR460-464 :: ID: 501322
Abstract
Heme oxygenase is an enzyme responsible for the rate-limiting step in the oxidative degradation of heme. Inducible and constitutive forms of heme oxygenase (HO-1 and HO-2) have been characterized. Compared with normal liver and kidney tissue, human colorectal carcinoma propagated in athymic nude mice demonstrated an increase in heme oxygenase activity. The enzyme activity in tumors was significantly inhibited after intraperitoneal administration of synthetic metalloporphyrins, zinc-deuteroporphyrin IX-2,4-bisglycol and cobalt-protoporphyrin. Application of metalloporphyrins led to simultaneous stimulation of tumor growth.
Keywords: heme oxygenase, Colorectal Carcinoma, Metalloporphyrins, Thymidine Kinase, Hemin
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
06 Mar 2024 : Clinical Research
Prevalence and Variation of Medical Comorbidities in Oral Surgery Patients: A Retrospective Study at Jazan ...Med Sci Monit In Press; DOI: 10.12659/MSM.943884
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952