01 July 1997
Effects of somatostatin analog octreotide and some other antiproliferative agents on growth of transplantable colonic cancer in mice
Marek Pawlikowski, Katarzyna Winczyk, Gabriel Mełeń-MuchaMed Sci Monit 1997; 3(4): BR465-467 :: ID: 501323
Abstract
Effects of a long-acting somatostatin analog, octreotide (SMS), cysteamine (CSH), tripeptide colon mitosis inhibitor (CMI), and of cytostatic agent 5-fluorouracil on growth of transplantable murine colonic cancer Colon 38 were investigated. Tumor weight and bromodeoxyuridine (BrDU) incorporation into the tumoral cell nuclei were considered as indices of the tumor growth tumor growth. BrDU labelling was also evaluated in non-neoplastic colon. It was found that only the treatments with 5-FU alone and 5-FU plus SMS resulted in a statistically significant decrease of the tumor weight. In turn, a statistically significant reduction in tumor cell proliferation (measured by BrDU incorporation) was found only after simultaneous treatment with 5-FU and SMS. In contrast to the action in tumors, SMS did not enhance the 5-FU effect on cell proliferation in the non-neoplastic colon. Some tendencies towards lower tumor weights and cell proliferation indices was also observed after other treatments. This study suggests that SMS and 5-FU act synergistically on the growth of the investigated tumor.
Keywords: colonic cancer, somatostatin, octreotide, Cysteamine, colon mitosis inhibitor, 5-fluorouracil
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
08 Mar 2024 : Clinical Research
Evaluation of Foot Structure in Preschool Children Based on Body MassMed Sci Monit In Press; DOI: 10.12659/MSM.943765
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952