03 November 1997
Evaluating the relationship between social stress intensity and rapidity of carcinogenesis in an animal modelZygmunt Steplewski, Katarzyna Steplewska-Mazur, Grzegorz Mazur, Henryk Jaskołecki, Magdalena Elsner
Med Sci Monit 1997; 3(6): BR753-757 :: ID: 501723
Social stressors evolving from individual and population interactions produce stress reactions in many organisms (including humans), influencing homeostasis and altering the activity of the immunological system. Earlier reports showed that social stress, produced by altering social relations in breeding animals, accelerated the formation and growth of adenocarcinoma in rats. The objective of the present study was to identify relationships between intensity of the stress reaction, expressed as blood corticosterone concentrations, and the rapidity of adenocarcinoma growth in these rats. Sprague-Dawley rats were used for the studies. Stress reaction were induced through changes in g the roup relations of the rats' progeny after birth. The induction of adenocarcinoma was provoked chemically through DMBA administration or through inoculation of cultured neoplastic cells. Corticosterone concentrations were evaluated radioimmunologically. The rate of the neoplastic process was evaluated by weighing the dissected tumors. The results indicated that adenocarcinoma, induced chemically or through inoculation of tumor cells, develops faster in those animals which were separated from their mothers after termination of suckling and were then raised individually, than in those which remained with their mothers. The most rapid growth of adenocarcinoma was recorded in those animals which were separated from their mothers, kept in groups for a period of two weeks and then put into individual cages. Acceleration of carcinogenesis corresponded to the strength of the stress reaction, expressed as blood corticosterone concentrations. The results obtained imply a promoting effect of stress reactions upon carcinogenic processes. A possible responsible factor is the immunosuppresive effect of some components of the stress reaction, for instance corticosteroides.
Keywords: carcinogenesis, tumor, Corticosterone, Stress
01 January 2023 : EditorialEditorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030
Med Sci Monit 2023; 29:e939357
26 January 2023 : EditorialEditorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread
Med Sci Monit In Press; DOI: 10.12659/MSM.939580
19 January 2023 : Clinical ResearchEvaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...
Med Sci Monit In Press; DOI: 10.12659/MSM.938892
19 January 2023 : Clinical ResearchDetermining the Impact of the COVID-19 Pandemic on Dental Care in the Serbian Adult Population: An Online Q...
Med Sci Monit 2023; 29:e939238
30 Jan 2023 : Clinical ResearchSplenic Artery Steal Syndrome in Patients with Liver Cirrhosis: A Retrospective Clinical Study
Med Sci Monit In Press; DOI: 10.12659/MSM.938998
27 Jan 2023 : Database AnalysisAssociation Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...
Med Sci Monit In Press; DOI: 10.12659/MSM.938554
27 Jan 2023 : Clinical ResearchProposal for a Simple Equation for Limb Muscle Weight Calculation
Med Sci Monit In Press; DOI: 10.12659/MSM.938606
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292