01 September 1998
Effect of radiotherapy and surgery on glyoxalase activities in larynx cancer patient erythrocytes
Danuta Piskorska, Alojzy Danch, Marian Dróżdż, Ewa Kopieczna-Grzebieniak, Grzegorz Namysłowski, Eugeniusz Czecior, Ewa NowińskaMed Sci Monit 1998; 4(5): CR840-845 :: ID: 502039
Abstract
The glyoxalase system is modulated during cell division and differentiation and may also play an important role in cellular radiosensitivity. Glyoxalase I and glyoxalase II metabolize methylglyoxal to D-lactic acid, via D-lactoylglutathione.The glyoxalase enzymes activities were measured in erythrocytes of 17 healthy subjects and 41 patients with cancer of the larynx. The activities of glyoxalase I and glyoxalase II were decreased in the patients group in comparison to the control group and were as follows: 31.47±6.66 mU/mg protein and 11.73±3.21 mU/mg protein, respectively (control group: 42.40±7.28 and 19.66±2.62), (p< 0.0001). The activities of both glyoxalase I and glyoxalase II increased in patient erythrocytes following radiotherapy and in patients following combined therapy - surgery and radiotherapy. This was not so following surgery in comparison to enzymes activities in patients with cancer of the larynx cancer before therapy. The changes in glyoxalases activities following radiotherapy did not significantly differ from control group glyoxalase I and glyoxalase II activities.These results suggest that the glyoxalase system is affected by erythrocytes radiation.
Keywords: glyoxalases, cancer of the larynx, Radiotherapy
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952