Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1998

GABA content and GAD activity in normal mouse mammary gland tissue and in 16/C mammary cancer cells

Maria Mazurkiewicz, Adam Opolski, Joanna Wietrzyk, Czesław Radzikowski, Zdzisław Kleinrok

Med Sci Monit 1998; 4(4): BR596-599 :: ID: 502105

Abstract

GABA ((-aminobutyric acid) is the brain's main inhibitory neurotransmitter. The highest level of GABA is found in the CNS. GABA presence and GAD (the key enzyme in GABA synthesis) activity were also detected in several non-neural tissues. We observed an increase in the GABA level and GAD activity in tumor tissues in comparison with normal tissue. Our study examined the GABA content and GADactivity in the normal mammary gland of healthy mice and in the 16/C adenocarcinoma mammary gland as an experimental model. Comparison between and within groups were made by one way analysis of variance (ANOVA). Our investigations demonstrated GABA presence and GAD activity in the normal mouse mammary gland tissue. We observed a significant increase in the GABA level and GAD activity in mouse 16/C mammary cancer cells in comparison with normal mammary gland skin. Tumor tissues showed a clear positive correlation between GABA levels and GAD activity. There were no significant differences in the GABA content and GAD activity between mammary gland skin coming from tumor bearing and healthy mice. An increase of the GABA level and GAD activity in tumor tissues could possibly reflect a local antitumor response, however, hypoxia of tumor cells could also be considered. The observed GABA metabolism pathway in mammary cancer compared with literature data concerning other tumors, can suggest the possibility of therapeutic usefulness of GABA-ergic system agonists such as baclophen.

Keywords: Neoplasms, breast cancer, GABA, GAD

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750