01 January 1998
Beneficial influence of antioxidants on the level of free radicals during reperfusion in acute limb ischemia in ratsPaweł Chęciński, Hanna Kraus, Łukasz Dzieciuchowicz, Jacek Kozlik, Przemysław Sosnowski, Marcin Gabriel, Stanisław Zapalski, Janusz Paluszak
Med Sci Monit 1998; 4(1): BR43-46 :: ID: 502823
The purpose of this study was to investigate the influence of chosen antioxidants on the reduction of destructive changes caused in the cells by the free oxygen radicals. Thirty-two male Wistar rats with surgically produced posterior limb acute ischemia were examined. The animals before reperfusion received either a single dose of the chosan antioxidant or no treatment at all. Using a method of measurement of the electron signal of paramagnetic resonance the level of free radicals was determined in tissue samples obtained during reperfusion. The activity of a isocitrate dehydrogenase and glucose-6-phosphate dehydrogenase in homogenized tissue samples was also measured. The administration of antioxidants significantly decreased the concentration of free radicals during reperfusion. A smaller reduction of activity of the examined enzymes was observed after treating with antioxidants. Administration of antioxidants has a beneficial influence on free radicals level during reperfusion.
Keywords: Ischemia-Reperfusion Injury, Free Radicals, Antioxidants
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