Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 January 1998

Beneficial influence of antioxidants on the level of free radicals during reperfusion in acute limb ischemia in rats

Paweł Chęciński, Hanna Kraus, Łukasz Dzieciuchowicz, Jacek Kozlik, Przemysław Sosnowski, Marcin Gabriel, Stanisław Zapalski, Janusz Paluszak

Med Sci Monit 1998; 4(1): BR43-46 :: ID: 502823

Abstract

The purpose of this study was to investigate the influence of chosen antioxidants on the reduction of destructive changes caused in the cells by the free oxygen radicals. Thirty-two male Wistar rats with surgically produced posterior limb acute ischemia were examined. The animals before reperfusion received either a single dose of the chosan antioxidant or no treatment at all. Using a method of measurement of the electron signal of paramagnetic resonance the level of free radicals was determined in tissue samples obtained during reperfusion. The activity of a isocitrate dehydrogenase and glucose-6-phosphate dehydrogenase in homogenized tissue samples was also measured. The administration of antioxidants significantly decreased the concentration of free radicals during reperfusion. A smaller reduction of activity of the examined enzymes was observed after treating with antioxidants. Administration of antioxidants has a beneficial influence on free radicals level during reperfusion.

Keywords: Ischemia-Reperfusion Injury, Free Radicals, Antioxidants

0 Comments

Editorial

01 August 2022 : Editorial  

Editorial: Long-Term Effects of Symptomatic and Asymptomatic SARS-CoV-2 Infection in Children and the Changing Pathogenesis of Common Childhood Viruses Driven by the COVID-19 Pandemic

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.937927

Med Sci Monit 2022; 28:e937927

In Press

05 Aug 2022 : Clinical Research  

A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Frac...

Med Sci Monit In Press; DOI: 10.12659/MSM.936923  

05 Aug 2022 : Clinical Research  

Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Progno...

Med Sci Monit In Press; DOI: 10.12659/MSM.937146  

04 Aug 2022 : Clinical Research  

Radiological Assessment of Prevalance and Quality of Periapical Status of Endodontic Treatments

Med Sci Monit In Press; DOI: 10.12659/MSM.936569  

01 Aug 2022 : Clinical Research  

Surgical Management of 48 Patients with Retrosternal Goiter and Tracheal Stenosis: A Retrospective Clinical...

Med Sci Monit In Press; DOI: 10.12659/MSM.936637  

Most Viewed Current Articles

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Nov 2020 : Review article  

Long-Term Respiratory and Neurological Sequelae of COVID-19

DOI :10.12659/MSM.928996

Med Sci Monit 2020; 26:e928996

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750