Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 November 1999

Plasma nitrate/nitrite levels in patients with colorectal carcinoma

Erika Szaleczky, Andra‡s Rosta, Hiroe Nakazawa, J‡anos FehŽer, Zsolt Tulassay, L‡aszlo Pro—nai

Med Sci Monit 1999; 5(6): CR1098-1100 :: ID: 503105

Abstract

Endogenously formed nitroso-compounds and nitrite-derived mutagens are believed to be involved in human cancer etiology. These nitroso-compounds can be formed from nitric oxide by macrophages and neutrophils by means of the inducible nitric oxide synthase. Increased nitric oxide synthase expression has been reported in patients with colon carcinoma. Since endogenous nitric oxide synthesis is responsible for the majority of plasma nitrate/nitrite levels, we investigated plasma nitrate/nitrite levels in colorectal carcinoma patients (mean age 66±2.2 y.). Thirteen healthy volunteers comprised the control group (mean age 28±1.9 y.). All patients had been diagnosed with adenocarcinoma (11 rectum, 12 colon, 2 both the rectum and colon), mostly within one year of the study and 50% of patients underwent surgery and/or chemotherapy within one month of the study.Thirteen patients were classified as stage B or C and 15 patients had stage D, according to the Dukes classification modified by Astler-Coller and Turnbull. Since cardiac failure and nitric oxide releasing drugs (such as nitroglycerine) may increase plasma nitrate/nitrite levels, patients had also been divided according to their medication and cardiac condition. Considering the total number of patients, cancer patients demonstrated no statistically different plasma nitrate/nitrite levels, in comparison with healthy controls. However, patients with a tumor diagnosed more than a half year prior to the study, had significantly higher nitrate/nitrite levels compared to the group of patients diagnosed within six months of the study (p=0.03). Patients who underwent chemotherapy within one month of the study, also demonstrated significantly higher nitrate/nitrite levels compared to the group of patients who had no chemotherapy during the past four weeks (p=0.04). Plasma nitrate/nitrite levels were higher in patients with no prior surgery. There was no statistically significant difference in patients when assessing the location of the tumor, presence or absence of distal metastasis, medication used or cardiac condition.Actual plasma nitrate/nitrite levels are indirect measures of malignant diseases. They do not reflect earlier staging, location or severity of the colorectal carcinoma but seem to positively correlate with the duration of the disease. Chemotherapy increases plasma nitrate/nitrite levels by enhancing cell degradation.

Keywords: peroxynitrite, Nitric Oxide, colorectal cancer

0 Comments

Editorial

01 January 2023 : Editorial  

Editorial: Current Status of Two Adjuvanted Malaria Vaccines and the World Health Organization (WHO) Strategy to Eradicate Malaria by 2030

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.939357

Med Sci Monit 2023; 29:e939357

SARS-CoV-2/COVID-19

26 January 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

19 January 2023 : Clinical Research  

Evaluation of Health-Related Quality of Life and Mental Health in 729 Medical Students in Indonesia During ...

Med Sci Monit In Press; DOI: 10.12659/MSM.938892  

27 December 2022 : Clinical Research  

Effect of Physiotherapy to Correct Rounded Shoulder Posture in 30 Patients During the COVID-19 Pandemic in ...

Med Sci Monit 2022; 28:e938926

In Press

27 Jan 2023 : Database Analysis  

Association Between Neutrophil-Lymphocyte Ratio and All-Cause Mortality in Critically Ill Patients with Chr...

Med Sci Monit In Press; DOI: 10.12659/MSM.938554  

27 Jan 2023 : Clinical Research  

Proposal for a Simple Equation for Limb Muscle Weight Calculation

Med Sci Monit In Press; DOI: 10.12659/MSM.938606  

26 Jan 2023 : Editorial  

Editorial: The XBB.1.5 (‘Kraken’) Subvariant of Omicron SARS-CoV-2 and its Rapid Global Spread

Med Sci Monit In Press; DOI: 10.12659/MSM.939580  

20 Jan 2023 : Clinical Research  

A Study of 42 Partially Edentulous Patients with Single-Crown Restorations and Implants to Compare Bone Los...

Med Sci Monit In Press; DOI: 10.12659/MSM.939225  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750