Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1999

Influence of selected antiarrhythmic drugs on the hemodynamic parameters in rabbit during methohexital anesthesia

Anna Wiktorowska, Jacek Owczarek, Daria Orszulak-Michalak

Med Sci Monit 1999; 5(4): BR623-629 :: ID: 503457


Cardiac arrhythmia can be a serious complication during general anesthesia of patients suffering from cardiac arrhythmia's and using antiarrhytmic drugs. The aim of the present study was to establish the path of lidocaine and verapamil influence hemodynamic parameters of rabbits during methohexital anesthesia. The experiments were performed on rabbits. Heart rate was counted according to ECG. Blood pressure was measured directly in the carotid artery. Cardiac output, stroke volume, and total peripheral resistance were estimated using the method of human 125J albumin dilution. Lidocaine administered simultaneously with methohexital weakens the effect of methohexital on blood pressure in rabbits. After the administration of methohexital with lidocaine heart rate was similar to the initial value, while as compared to methohexital alone it was higher in the second hour of the experiment. After methohexital-lidocaine administration an increase in blood pressure and heart rate was observed, as compared to methohexital alone and lidocaine alone. Decrease in blood pressure was observed after the administration of verapamil and methohexital. Combined administration of these drugs enhanced the hypotensive effect of both drugs. Administration of methohexital-verapamil caused statistically significant decrease in peripheral resistance as compared to the inital value and also to methohexital alone.

Keywords: general anesthesia, antiarrhythmic drugs, Hemodynamics

Add Comment 0 Comments


01 February 2024 : Editorial  

Editorial: Global Health Concerns as Vaccine-Preventable Infections Including SARS-CoV-2 (JN.1), Influenza, Respiratory Syncytial Virus (RSV), and Measles Continue to Rise

Dinah V. Parums

DOI: 10.12659/MSM.943911

Med Sci Monit 2024; 30:e943911


In Press

19 Feb 2024 : Clinical Research  

Diagnostic Accuracy of Ileocolic Artery and Vein Diameter for Acute Appendicitis

Med Sci Monit In Press; DOI: 10.12659/MSM.943846  


23 Feb 2024 : Clinical Research  

Early Mobilization in Pediatric Critical Care: Exploring the Gap Between Theory and Practice in Saudi Arabia

Med Sci Monit In Press; DOI: 10.12659/MSM.942467  


01 Feb 2024 : Review article  

Enhancing Patient Adherence to Newly-Prescribed Medicine for Chronic Diseases: A Comprehensive Review and C...

Med Sci Monit In Press; DOI: 10.12659/MSM.942923  

10 Jan 2024 : Clinical Research  

Efficacy of Bakri Intrauterine Balloon in Managing Postpartum Hemorrhage: A Comparative Analysis of Vaginal...

Med Sci Monit In Press; DOI: 10.12659/MSM.943072  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387


17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750