Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

01 July 1999

Significance of densitometry and biochemical tests in diagnosis of osteoporosis in children suffering from juvenile rheumatoid arthritis

Danuta Chlebna-Sok—ół, Henryka Bró—zik, Tadeusz Bujnowski, Małgorzata Biernacka, Elżbieta Loba-Jakubowska, Anna Sikora, Elżbieta Smolewska

Med Sci Monit 1999; 5(4): CR720-725 :: ID: 504497


Background:The aim of this study was to evaluate the role of different tests in the diagnosis of osteoporosis, in children suffering from juvenile rheumatoid arthritis (JRA), as well as to assess the correlation between test results and clinical disease symptoms.
Material/Methods:Tests were performed in 30 children aged between 5-18 years (24 girls, 6 boys), suffering from juvenile rheumatoid arthritis. We evaluated the bone mineral density (BMD - g/cm2, Z-score) by means of dual energy X-ray absorptiometry (DEXA method) using the 'total body' program in all children and in some by means of the lumbar vertebral column using the 'spine' program. Moreover, we also determined the serum calcium, phosphorus and magnesium levels, as well as the urine excretion of these ions and that of total hydroxyproline. We measured the activity of alkaline phosphatase and its bone isoenzyme, as well as 25-hydroxyvitamin D and parathyroid hormone levels.
Results:Based on bone densitometry results osteoporosis was diagnosed in 12 of the patients with JRA (40%). These children demonstrated clinical and radiological manifestations of osteoporosis. Distinct biochemical test abnormalities included decreased parathyroid hormone, 25-hydroxycholecalciferol vitamin D and magnesium blood concentrations and increased hydroxyproline excretion with urine. Such abnormalities also appeared in children with JRA but without osteoporosis, although less frequently. The longer the disease had lasted the lower the bone mineral density.
Conclusions:Densitometry should be considered as the most important and objective method of diagnosing osteoporosis in children with JRA. Urine hydroxyproline excretion seems to be of great practical significance amongst biochemical indices.

Keywords: densitomery, Diagnosis, Osteoporosis

Add Comment 0 Comments

675 3


01 December 2023 : Editorial  

Editorial: Outbreaks of Post-Pandemic Childhood Pneumonia and the Re-Emergence of Endemic Respiratory Infections

Dinah V. Parums

DOI: 10.12659/MSM.943312

Med Sci Monit 2023; 29:e943312


In Press

01 Dec 2023 : Clinical Research  

Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St...

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Review article  

Decoding the Neurological Sequelae of General Anesthesia: A Review

Med Sci Monit In Press; DOI:  

30 Nov 2023 : Clinical Research  

Enhanced Pain Relief and Muscle Growth in Individuals with Low Back Instability: The Impact of Blood Flow R...

Med Sci Monit In Press; DOI:  

29 Nov 2023 : Clinical Research  

Comparative Analysis of Intramedullary Nail versus Plate Fixation for Fibula Fracture in Supination Externa...

Med Sci Monit In Press; DOI:  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379


14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990


08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292


Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750