01 July 1999
Analysis of distant sequelae of congenital toxoplasmosis in children and adults
Wanda Kocięcka, Włodzimierz Paprzycki, Hanna Twardosz-PawlikMed Sci Monit 1999; 5(4): CR726-731 :: ID: 504505
Abstract
The study aimed at presenting distant sequelae of congenital toxoplasmosis in 15 children and in 5 adults who were not treated in the course of the first year of life. The retrospective analysis as well as a set of supplementary studies (neurologic, ophthalmologic studies, computerised tomography of the head (CT), serological examination using ELISA test (Vidas, bio Merieux)) were performed to demonstrate IgM and IgG antibodies against T. gondii antigen. Type of neurological disturbances varied and ranged between 5.0% do 50.0% of cases. CT lesions included widening of lateral ventricles (30.0%), their asymmetry (35.0%), intracranial calcifications (65.0%) located mainly in lateral ventricles and in both hemispheres (35.0%). Lesions in the organs of sight included mainly amblyopia due to diffuse chorioretinal scars (70.0%), located mainly within retinal macula (50.0%). In all the patients, IgG antibodies were present (ELISA, DA), but in children they reached high titres and in two of them they were accompanied by IgM antibodies because of reactivation of the pathological process. The complex studies performed in the observed 20 patients proved that clinical pathology in the form of CNS lesions (85.0%) and lesions in the organs of sight (80.0%) represent late sequelae of congenital toxoplasmosis in patients who remained undiagnosed and were not treated in the first year of life.
Keywords: ocular and CNS pathology, late sequelae, Congenital toxoplasmosis
529 0
Editorial
01 October 2023 : Editorial
Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air PollutionDOI: 10.12659/MSM.942672
Med Sci Monit 2023; 29:e942672
In Press
02 Oct 2023 : Clinical Research
Comparison of Nanocrystalline Hydroxyapatite Bone Graft with Empty Defects in Long Bone Fractures: A Retros...Med Sci Monit In Press; DOI: 10.12659/MSM.941112
02 Oct 2023 : Review article
Circadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic OpportunitiesMed Sci Monit In Press; DOI: 10.12659/MSM.942215
30 Sep 2023 : Clinical Research
Influence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Pat...Med Sci Monit In Press; DOI: 10.12659/MSM.940128
28 Sep 2023 : Clinical Research
Trends in Hospitalization Duration for Rare Diseases: A Retrospective Analysis of Sarcoidosis, Still's Dise...Med Sci Monit In Press; DOI: 10.12659/MSM.941536
Most Viewed Current Articles
13 Nov 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...DOI :10.12659/MSM.932788
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical Research
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...DOI :10.12659/MSM.935379
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review article
A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...DOI :10.12659/MSM.936292
Med Sci Monit 2022; 28:e936292