01 January 1999
Effect of probucol on plasma apolipoproteins C-III in Apo B- and non-Apo B - containing lipoproteins in patients with cardiovascular artery disease
Barbara Millo, Barbara Torbus-Lisiecka, Zdzisława Kornacewicz-Jach, Marek NaruszewiczMed Sci Monit 1999; 5(1): CR111-117 :: ID: 505270
Abstract
The distribution of apolipoproteins C-III (apo C-III) among lipoproteins may be causatively associated with cardiovascular artery disease (CAD). The objective of this study was to evaluate the changes in plasma concentration of lipids, lipoproteins and apolipoproteins in CAD patients, qualified for coronary by-pass surgery, before and after short-time administration of probucol. 19 patients (mean 53±12 years) with angiographically confirmed cardiovascular artery disease were treated with probucol (2x500 mg/day) for 3 weeks. Patients were evaluated before and after the drug administration. Levels of total apolipoproteins C-III (apo C-III) and apo C-III in plasma devoided of apo B-containig particles (apo C-III-nonLp-B) by immunoprecipitation using specific anti-apo B antiserum, were measured by electroimmunoassay. Apo C-III concentrations in apo B-containing lipoproteins (apo-C-III-LpB) were calculated by difference between total and apo C-III-nonLpB. Almost all lipid parameters significantly decreased after probucol therapy: total cholesterol from 254.8±40.1 to 213.3±44.5 mg/dl, LDL-cholesterol from 181.5±37.0 to 141±38.9 mg/dl, HDL from 40.0±5.3 to 33.6±5.5 mg/dl, triglycerides from 153.3±35.5 to 128.0±48.1mg/dl. Total apoC-III decreased from 27.3±7.2 to 23.2±8.5 mg/l, apo C-III-nonLpB from 18.8±6.8 to 13.2±5.1 mg/l, the apo C-III ratio (apo C-III-nonLp- B/apo C-III-Lp-B) changed from 2.55±1.56 to 1.47±0.63. The relationship between apo C-III, apo C-III-non- Lp-B, apo C-III-Lp-B and triglycerides remarkably changed after probucol therapy: r=0.41 (NS) vs. r=0.80 (p<0.001); r=0.42 (NS) vs. r=0.78 (p<0.001) and r=0.04 (NS) vs. r=0.55 (p<0.05), respectively. The different relationship was observed also between apo C-III-Lp-B and HDL3-cholesterol (r = -0.45, p<0.05 vs. r =-0.07, NS) Our results confirmed that probucol influences on lipid metabolism and apo C-III is involved in this process. Probucol decreased apo C-III mainly in lipoproteins without apo B, it was possible that probucol rearranged the action of apo-C-IIILpB.
Keywords: CAD, Probucol, Apolipoprotein C-III
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952