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01 January 1999

Leptin - an anti-obesity hormone obtained from fat cells

Sławomir Manysiak, Grażyna Odrowˆąż-Sypniewska

Med Sci Monit 1999; 5(1): RA162-167 :: ID: 505559

Abstract

The obese gene product leptin, exclusively expressed in white adipose tissue constitutes the most essential link of the feedback loop maintaining energy balance by signaling to the hypothalamus centers. Leptin expression is increased in obese rodents and humans and regulated by feeding, insulin, glucocorticoids and sex hormones. Men have significantly lower serum leptin levels than women at any given measure of obesity. Neither ob gene mutations nor leptin receptor mutations seem to be responsible for human obesity. Obese humans are probably leptin-resistant due to defective post-receptor signaling.

Keywords: Obesity, adipocytes-metabolism, lepid

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750