Searching for a genetic risk profile in end-stage renal disease
Monika Buraczyńska, Andrzej KsiążekMed Sci Monit 2001; 7(6): RA1376-1380 :: ID: 508483
Abstract
There is a strong evidence that both, genetic factors and environment, affect the development of end-stage renal disease (ESRD). The factors that initiate renal failure are probably different from those contributing to its progression. Some factors involved in the progression of nephropathy are already identified, like elevated blood pressure, hypercholesterolemia or hyperparathyroidism. Molecular genetic techniques are extensively applied to developing strategies for detection of human renal failure genes. The candidate gene approach for finding an association between polymorphic DNA markers and disease was successfully used in studying genes of the renin-angiotensin system, especially those coding angiotensin I-converting enzyme, angiotensinogen and angiotensin type 1 receptor. Several other genes, for example growth factors and cytokine genes, nitric oxide synthase or genes of the kallikrein-kinin system are being evaluated using this approach. Identification of candidate genes associated with end-stage renal disease will create a need for testing several disease loci simultaneously. Subsets of predictive genetic markers will be developed for routine use in clinical practice. Recognizing genetic changes affecting the initiation and progression of renal failure will have important clinical implications, involving testing individuals who are genetically susceptible but yet unaffected. It will make possible identification of individuals at a higher risk for renal failure and help in the choice of diagnostic tests as well as in planning therapeutic interventions.
Keywords: genetic risk profile, renal disease
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952