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Plasma levels of slCAM-1 in patients affected by psoriasis: no relation to disease severity

Dorota Krasowska, Grażyna Chodorowska, Maria Kozioł, Dorota Czelej

Med Sci Monit 2000; 6(2): CR353-355 :: ID: 508489

Abstract

The aim of the study was to determine the plasma level of sICAM-1 in acute psoriatic patients in contrast to normal subjects. Moreover, we have tried to answer whether disease severity index (PASI) correlates with plasma level of sICAM-1. We have determined the plasma levels of sICAM-1 by ELISA (Genzyme Corporation) in 23 patients with acute psoriasis before and after the treatment of the disease and in 11 controls. Patients with acute psoriasis have displayed higher levels of sICAM-1 (306.4I226.8 ng/ml) compared with the controls (141.2I49.2 ng/ml) and the same patients after clearing of the disease (154.7I126.7 ng/ml). We have not found any correlation between plasma levels of sICAM-1 and severity index of psoriasis (PASI). We have concluded: the plasma levels of sICAM-1 are not related to disease severity in acute psoriasis. Clearing of the psoriasis is followed by significant fall of plasma sICAM-1.
key words: soluble intercellular cell adhesion molecule-1 • plasma • acute psoriasis • PASI

Keywords: PASI, acute psoriasis, Plasma, soluble intercellular cell adhesion molecule-1

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750