01 December 2007
Evaluation of hawthorn extract on immunomodulatory biomarkers in a pressure overload model of heart failureBarry E. BleskeABCDEFG, Issam ZinehABCDEFG, Hyun Seok HwangABCDEF, Gregory J. WelderBCDEF, Michael M.J. GhannamBCDEF, Marvin O. BoluytABCDEFG
Med Sci Monit 2007; 13(12): BR255-258 :: ID: 563758
Hawthorn extract (Crataegeus sp.) a botanical complementary and alternative medicine is often used to treat heart failure. The mechanism(s) by which hawthorn extract may treat heart failure is unknown but may include, theoretically, immunological effects. Therefore, the purpose of this study is to determine the effect of hawthorn extract on the immunomodulatory response in a pressure overload model of heart failure.
Material and Method
A total of 62 male Sprague-Dawley rats were randomized to either aortic constriction + vehicle (AC; n=15), aortic constriction + hawthorn 1.3 mg/kg (HL, n=17), aortic constriction + hawthorn 13 mg/kg (HM, n=15), or aortic constriction + hawthorn 130 mg/kg (HH, n=15). Six months after surgical procedure animals were sacrificed and plasma samples obtained for the measurement of the following immunomodulatory markers: interleukin (IL) IL-1ss, IL-2, IL-6, IL-10; and leptin.
The mortality rate following 6 months of aortic constriction was 40% in the AC group compared to 41%, 60%, and 53% for the HL, HM, and HH groups respectively (P>0.05 compared to AC). Aortic constriction produced a similar increase in the left ventricle/body weight ratio for all groups. Hawthorn extract had no effect on the immunomodulatory markers measured in this study, although there appeared to be a trend suggesting suppression of IL-2 plasma concentrations.
In this animal model of heart failure, hawthorn extract failed to significantly affect the immunomodulatory response characterized after 6 months of pressure overload at a time when approximately 50% mortality was exhibited. Mechanisms other than immunological may better define hawthorn's effect in treating heart failure.
Keywords: Random Allocation, Plant Extracts - therapeutic use, Phytotherapy, Heart Failure - immunology, Cytokines - metabolism, Crataegus - chemistry, Constriction, Pathologic - complications, Biological Markers - metabolism, Aorta - physiopathology
01 October 2023 : EditorialEditorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air Pollution
Med Sci Monit 2023; 29:e942672
02 Oct 2023 : Clinical ResearchComparison of Nanocrystalline Hydroxyapatite Bone Graft with Empty Defects in Long Bone Fractures: A Retros...
Med Sci Monit In Press; DOI: 10.12659/MSM.941112
02 Oct 2023 : Review articleCircadian Rhythms in Cardiovascular Function: Implications for Cardiac Diseases and Therapeutic Opportunities
Med Sci Monit In Press; DOI: 10.12659/MSM.942215
30 Sep 2023 : Clinical ResearchInfluence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Pat...
Med Sci Monit In Press; DOI: 10.12659/MSM.940128
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990
08 Mar 2022 : Review articleA Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...
Med Sci Monit 2022; 28:e936292