Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 November 1999

Antiretroviral therapy and its influence on the stage of brain damage in patients with HIV – 1H MRS evaluation

Eugeniusz Tarasów, Alicja Wiercińska-Drapało, Jerzy Jaroszewicz, Agnieszka Orzechowska-Bobkiewicz, Wojciech Dzienis, Danuta Prokopowicz, Jerzy Walecki

Med Sci Monit 2004; 10(3): 101-106 :: ID: 878557

Abstract

Background: MR proton spectroscopy (1H MRS) enables early detection of metabolic changes, which occur in the course of AIDS Dementia Complex Syndrome (ADC). The goal of the study was the evaluation of highly active antiretroviral therapy (HAART) and its influence on the character and intensity of metabolic changes in brain 1H MRS spectra in clinically asymptomatic HIV-infected patients as well as search for correlation between the treatment and 1H MR spectroscopy results and immune deficit degree.
Material and Methods: In the group of 20 HIV+ patients, the examination of the central nervous system (CNS), MR and 1H MRS were conducted twice: before HAART treatment and during the therapy; on average after 6 months (4–9 months of treatment).
Results: The levels of NAA/Cr in the control MRS examination were close to the values observed before treatment. However, statistically significant increase in NAA/Cho ratio (p<0.05) was noticed. The control examination showed statistically decrease of Cho/Cr and mI/Cr ratios, though statistically insignificant (p>0.05). NAA and Cr contents in reference to the signal of non-suppressed water increased insignificantly in the follow-up examination. However, statistically significant decrease in Cho/H2O and mI/H2O levels (p<0.05) was observed.
Conclusion: The therapy with HAART affects normalization of metabolite levels in the central nervous system in clinically asymptomatic HIV+ patients and diminishes the risk of ADC occurrence. Myoinositol and choline levels estimated in 1H MRS might be the indices for antiretroviral treatment efficacy.

Keywords: highly active retroviral therapy, brain damage, MR spectroscopy, AIDS Dementia Complex - pathology, Antiretroviral Therapy, Highly Active, Aspartic Acid - metabolism, Choline - metabolism, Creatine - metabolism, Inositol - metabolism, Magnetic Resonance Spectroscopy - methods

Add Comment 0 Comments

Editorial

01 June 2025 : Editorial  

Editorial: Harmonization and Publication of the 2025 Updates of the CONSORT and SPIRIT Statements for Clinical Trials

Dinah V. Parums

DOI: 10.12659/MSM.949923

Med Sci Monit 2024; 31:e949923

In Press

Clinical Research  

Comparative Analysis of Oxidative Stress Biomarkers in 50 Primary Open-Angle Glaucoma Patients

Med Sci Monit In Press; DOI: 10.12659/MSM.948665  

Review article  

Linking Triglyceride-Glucose Index to Spontaneous Intracerebral Hemorrhage: Mechanisms and Predictive Insights

Med Sci Monit In Press; DOI: 10.12659/MSM.948695  

Clinical Research  

Comparative Spectrophotometric Assessment of Crown Discoloration from Diverse Endodontic Sealers

Med Sci Monit In Press; DOI: 10.12659/MSM.947874  

Clinical Research  

Ultrasound Measurement of Pupillary Dilation Reflex During Induction of General Anesthesia Using Sufentanil...

Med Sci Monit In Press; DOI: 10.12659/MSM.948209  

Most Viewed Current Articles

17 Jan 2024 : Review article   9,044,913

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

16 May 2023 : Clinical Research   704,022

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

01 Mar 2024 : Editorial   32,751

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and ...

DOI :10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

28 Jan 2024 : Review article   26,945

A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future

DOI :10.12659/MSM.943912

Med Sci Monit 2024; 30:e943912

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750