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03 October 2022 : Clinical Research  

Effect of Vitamin D Concentration on Course of COVID-19

Magdalena Dominika Szerszeń12ABDEF*, Aleksandra Kucharczyk3BDEF, Katarzyna Bojarska-Senderowicz3BDEF, Monika Pohorecka32ADEF, Andrzej Śliwczyński4CD, Janusz Engel5C, Tomasz Korcz6B, Dariusz Kosior7A, Irena Walecka8A, Wojciech Stefan Zgliczyński9A, Waldemar Wierzba1011G, Adam Jerzy Sybilski32ADF

DOI: 10.12659/MSM.937741

Med Sci Monit 2022; 28:e937741

Abstract

BACKGROUND: The course of COVID-19 disease is associated with immune deregulation and excessive release of pro-inflammatory cytokines. Vitamin D has an immunomodulatory effect. We aimed to assess the possible correlation between the incidence and severity of SARS-CoV-2 infection and serum vitamin D concentration.

MATERIAL AND METHODS: A total of 505 successive patients admitted to a COVID-19-dedicated hospital were included in the retrospective analysis. Serum 25-hydroxyvitamin D (25-OHD) levels and SARS-CoV-2 RT-PCR throat swab test results were determined for each patient. The course of COVID-19 was assessed on the basis of the serum Vitamin Modified Early Warning Score (MEWS), which includes respiratory rate, systolic blood pressure, heart rate, temperature, and state of consciousness), as well as number of days spent in the intensive care unit (ICU) and need for oxygen therapy.

RESULTS: There was no difference in 25-OHD concentration between COVID-19-confirmed and negative results of the PCR tests. No correlation was found between serum 25-OHD in the COVID(+) group and the need for and time spend in the ICU, as well as the MEWS score. Multivariate analyses showed a positive correlation between need for oxygen therapy and lower 25-OHD concentration, as well as older age (P<0.001) and similar positive correlation between need for ventilation therapy with lower 25-OHD concentration, as well as older age (P=0.005).

CONCLUSIONS: Our findings do not support a potential link between vitamin D concentrations and the incidence of COVID-19, but low vitamin D serum level in COVID-19 patients might worsen the course of the disease and increase the need for oxygen supplementation or ventilation therapy.

Keywords: 1,25-dihydroxy-16,23-diene vitamin D3, COVID-19, SARS-CoV-2, Calcitriol

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Editorial: Rebound COVID-19 and Cessation of Antiviral Treatment for SARS-CoV-2 with Paxlovid and Molnupiravir

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.938532

Med Sci Monit 2022; 28:e938532

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Effect of Vitamin D Concentration on Course of COVID-19

Med Sci Monit 2022; 28:e937741

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750