18 December 2021: Clinical Research
Age-Stratified Cut-Off Values for Serum Levels of N-Terminal ProB-Type Natriuretic Peptide and Mortality from Sepsis in Children Under Age 18 Years: A Retrospective Study from a Single Center
Yan-na Sun 1ABCE* , Chun-wang Lin 1ABCDEF** , Wen Tang 2BF* , Jiang-ping Zhang 1CFDOI: 10.12659/MSM.933400
Med Sci Monit 2021; 27:e933400
Table 1 Clinical characteristics of pediatric patients with sepsis at administration.
| Patients with sepsis | <1 year | 1–3 years | 4–6 years | 7–18 years | P value |
|---|---|---|---|---|---|
| Subjects, n | 85 | 139 | 56 | 47 | – |
| Sex, Male/Female (%) | 52.2/48.6 | 51.2/46.9 | 53.4/46.8 | 52.3/48.4 | 0.83 |
| Age (median year) | 0.4±0.2 | 1.4±0.4 | 4.8±0.7 | 8.8±1.5 | 0.27 |
| Body temperature (°C) | 39±0.8 | 40±0.7 | 40±0.5 | 39±0.7 | 0.47 |
| Heart rate (time/min) | 126±20.5 | 122±24.8 | 114±16.7 | 101±15.5 | |
| Breath rate (time/min) | 58±4 | 54±5 | 50±4 | 46±3 | |
| NT-proBNP (ng/L) | 5348.7 | 4486.8 | 4107.4 | 3829.6 | |
| Plasma glucose (mmol/L) | 10.5±1.3 | 9.5±1.5 | 9.1±0.9 | 8.2±0.6 | 0.15 |
| WBC increase, ×10/L | 19±3.4 | 17±2.9 | 16±3.3 | 16±2.3 | 0.24 |
| WBC decrease, ×10/L | 3±0.5 | 3±0.1 | 3±0.3 | 3±0.4 | 0.37 |
| Platelet (10×10/L) | 85±24 | 74±18 | 76±25 | 79±17 | 0.16 |
| Hemoglobin (g/L) | 71±15 | 69±17 | 73±12 | 80±14 | 0.06 |
| STB (mmol/L) | 95±25 | 77±29 | 54±13 | 50±15 | |
| ALT(U/L) | 67±14 | 72±16 | 49±17 | 47±19 | |
| CRP (mg/L) | 40±5.5 | 43±14.5 | 31±1.9 | 30±1.6 | |
| PCT (mg/L) | 15±1.5 | 16±1.6 | 14±0.7 | 13±0.9 | 0.17 |
| SCr (μmol/L) | 110±24 | 113±18 | 95±25 | 96±27 | 0.21 |
| Blood lactic acid (mmol/L) | 6±1.2 | 5±1.4 | 4±0.8 | 4±0.7 | |
| aPTT (s) | 66±15 | 68±12 | 50±13 | 52±18 | 0.12 |
| SaO2 (%) | 56±12 | 52±16 | 58±09 | 57±11 | 0.25 |
| EF (%) | 44±11 | 46±09 | 47±10 | 46±07 | 0.31 |
| SBP (mmHg) | 67±13 | 71±11 | 75±08 | 85±17 | |
| Urine volume (ml·kg·min) | 0.29±0.08 | 0.30±0.06 | 0.31±0.04 | 0.31±0.03 | 0.22 |
| Capillary filling (s) | 3±1.0 | 3±1.0 | 3±1.0 | 4±1.0 | 0.09 |
| NT-proBNP – N-terminal fragment of proB-type natriuretic peptide; WBC – white blood cell; STB – serum total bilirubin; ALT – alanine transaminase; CRP – C reaction protein; PCT – procalcitonin; SCr – blood creatinine; aPTT – activated partial thromboplastin time; SaO2 – arterial oxygen saturation; EF – ejection fraction; SBP – systolic blood pressure. | |||||