04 December 2021: Clinical Research
A Pilot Randomized Controlled Trial of Intermittent Theta Burst Stimulation as Stand-Alone Treatment for Post-Stroke Aphasia: Effects on Language and Verbal Functional Magnetic Resonance Imaging (fMRI)
Jane B. Allendorfer 1BCDEF* , Rodolphe Nenert 1BCDE , Jennifer Vannest 2ABCDE , Jerzy P. Szaflarski 13ABCDEFGDOI: 10.12659/MSM.934818
Med Sci Monit 2021; 27:e934818
Table 2 Variables for the study participants who completed at least the first 2 fMRI visits (T1, T2), and those who returned for a follow-up visit 3 months post-treatment (T3). Participants are grouped according to receiving sham (Tx0) and active iTBS (Tx123) treatment.
| Variable | T1: Tx0 (n=6) | T1: Tx123 (n=18) | T2: Tx0 (n=6) | T2: Tx123 (n=18) | T3: Tx0 (n=5) | T3: Tx123 (n=13) |
|---|---|---|---|---|---|---|
| BNT | 41 (13.6) | 29.7 (20.1) | 48.8 (10.3) | 35.6 (21.0) | 47.6 (9.6) | 28.1 (23.5) |
| SFT | 25.5 (8.9)* | 12.8 (10.3)* | 29.2 (9.6) | 14.6 (11.2) | 30.4 (5.3) | 13.6 (11.8) |
| COWAT | 9.3 (5.7) | 7.2 (6.4) | 10.2 (5.6) | 8.7 (7.9) | 12.6 (5.5) | 7 (7.1) |
| Complex ideation | 8.5 (4.4) | 6.7 (2.8) | 9.2 (3.8) | 6.5 (3.5) | 9.8 (3.8) | 6.8 (3.3) |
| PPVT | 188 (24.2) | 184 (25.6)a | 184.2 (15.6) | 185.8 (29.6)a | 199 (9.5) | 175.6 (35.0) |
| WAB-R Aphasia Quotient* | 83.1 (12.6)* | 58.4 (29.7),a | 80.1 (12.4)a | 57.9 (30.8)c | 84.4 (11.1) | 61.5 (33.1) |
| WAB-R Apraxia Total# | 57 (2.8)# | 50.9 (11.7),a | 57.2 (3.3)a | 50.3 (11.6)c | 59.2 (0.8) | 52.7 (9.2) |
| Mini-CAL | 55.3 (17.0)b | 42.5 (10.8)e | 50 (7.0)b | 47.8 (16.4)e | 49.7 (14.0)b | 53.2 (12.9)c |
| fMRI Verb Generation Task | ||||||
| Correct trials for “say verbs”# | 2.4 (2.1),a | 0.4 (1.1),d | 3.4 (4.5)a | 0.6 (1.4)d | 4 (4.2)a | 2.1 (3.5)e |
| Non-verb words for “say verbs” | 18 (12.9)a | 8.7 (7.1)d | 14.4 (15.5)a | 12.1 (9.2)d | 15 (16.1)a | 13.5 (11.6)e |
| Correct trials for “repeat nouns”*** | 12.8 (1.6),a | 5.2 (5.2),d | 13 (2.1)a | 7 (5.6)d | 14 (1.4)a | 7.9 (4.7)e |
| fMRI Verbal Paired Associates Task | ||||||
| Correct trials for “read”** | 26.5 (4.7),b | 12.8 (11.3),f | 27.6 (3.8)a | 19 (11.3)g | 27.2 (4.7) | 12.4 (12.9)c |
| Correct trials for “generate”# | 11.3 (4.4),b | 5.4 (6.7),f | 14.2 (5.0)a | 9.3 (8.5)g | 15.4 (8.1) | 7.2 (8.9)c |
| Post-scan Recognition Memory | ||||||
| Correct memory for “read”* | 20.8 (4.5),a | 14.1(6.5),b | 22.3 (5.2) | 15.4 (7.1)b | 17.4 (12.3) | 18.7 (7.9) |
| Correct memory for “generate”* | 20.8 (5.2),a | 12.4 (7.0),b | 20 (5.3) | 13.6 (6.8)b | 17.4 (12.3) | 15.6 (6.8) |
| Scores reported as mean (SD) for each variable. Tx0 and Tx123 groups compared at baseline using 2-sample t-tests. * ** *** # 0.05≤ a Missing data for 1 subject; b missing data for 2 subject; c missing data for 3 subjects; d missing data for 4 subjects; e missing data for 5 subjects; F missing data for 6 subjects; g missing data for 7 subjects. | ||||||