Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma; Wenpei Zhang; Xiaochen Wang; Huili Jiang; Li Tang; Wen Yang; Qianyan Kang; Juan Cao

doi:10.12659/MSM.937702

30 January 2023: Clinical Research

Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma ^1ABDEF* , Wenpei Zhang ^2BC* , Xiaochen Wang ^2BC* , Huili Jiang ^3BF , Li Tang ^3BF , Wen Yang ^3BF , Qianyan Kang ^1A* , Juan Cao ^3BF

DOI: 10.12659/MSM.937702

Med Sci Monit 2023; 29:e937702

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Table 4 Full results for single marker based association analyses.

CHR	SNP	A1	A2	Test	Cataract+	Cataract−	χ2	DF	P-value
2	rs2278117	A	G	GENO	37/322/667	71/662/1403	0.24	2	0.89
2	rs2278117	A	G	ALLELIC	396/1656	804/3468	0.21	1	0.65
2	rs142350606	G	A	GENO	7/123/896	13/269/1854	0.29	2	0.87
2	rs142350606	G	A	ALLELIC	137/1915	295/3977	0.11	1	0.74
2	rs890069	C	T	GENO	63/349/614	71/632/1433	22.97	2	1.03×10
2	rs890069	C	T	ALLELIC	475/1577	774/3498	22.13	1	2.55×10
2	rs16859293	G	A	GENO	2/64/960	2/115/2019	–	–	–
2	rs16859293	G	A	ALLELIC	68/1984	119/4153	1.35	1	0.25
2	rs79110076	A	C	GENO	2/68/956	2/124/2010	–	–	–
2	rs79110076	A	C	ALLELIC	72/1980	128/4144	1.19	1	0.28
2	rs75978038	T	G	GENO	2/49/975	2/115/2019	–	–	–
2	rs75978038	T	G	ALLELIC	53/1999	119/4153	0.22	1	0.64
2	rs7604252	T	C	GENO	16/191/819	23/402/1711	1.33	2	0.51
2	rs7604252	T	C	ALLELIC	223/1829	448/3824	0.21	1	0.65
2	rs66540381	G	A	GENO	134/474/418	287/995/854	0.19	2	0.91
2	rs66540381	G	A	ALLELIC	742/1310	1569/2703	0.19	1	0.66
2	rs117718684	A	G	GENO	2/121/903	6/261/1869	–	–	–
2	rs117718684	A	G	ALLELIC	125/1927	273/3999	0.21	1	0.65
12	rs117880663	A	G	GENO	2/62/962	2/111/2023	–	–	–
12	rs117880663	A	G	ALLELIC	66/1986	115/4157	1.37	1	0.24
12	rs12370429	G	A	GENO	130/462/434	263/944/929	0.41	2	0.82
12	rs12370429	G	A	ALLELIC	722/1330	1470/2802	0.37	1	0.54
12	rs11051044	T	C	GENO	5/131/890	6/265/1865	0.95	2	0.62
12	rs11051044	T	C	ALLELIC	141/1911	277/3995	0.34	1	0.56
12	rs74450722	C	A	GENO	3/86/937	4/171/1961	–	–	–
12	rs74450722	C	A	ALLELIC	92/1960	179/4093	0.29	1	0.59
12	rs6487934	A	G	GENO	77/402/547	173/846/1117	0.48	2	0.79
12	rs6487934	A	G	ALLELIC	556/1496	1192/3080	0.45	1	0.50
12	rs17739338	T	C	GENO	2/51/973	7/192/1937	–	–	–
12	rs17739338	T	C	ALLELIC	55/1997	206/4066	16.07	1	6.10×10
12	rs7134998	T	A	GENO	24/232/770	43/478/1615	0.39	2	0.82
12	rs7134998	T	A	ALLELIC	280/1772	564/3708	0.24	1	0.63
12	rs201229668	A	T	GENO	2/64/960	4/150/1982	–	–	–
12	rs201229668	A	T	ALLELIC	68/1984	158/4114	0.60	1	0.44
12	rs117381590	G	A	GENO	12/222/792	32/470/1634	0.62	2	0.73
12	rs117381590	G	A	ALLELIC	246/1806	534/3738	0.34	1	0.56
12	rs146271709	C	T	GENO	2/60/964	2/103/2031	–	–	–
12	rs146271709	C	T	ALLELIC	64/1988	107/4165	1.99	1	0.16
12	rs148120853	T	C	GENO	2/68/956	2/120/2014	–	–	–
12	rs148120853	T	C	ALLELIC	72/1980	124/4148	1.70	1	0.19
12	rs184106436	T	A	GENO	2/53/971	2/128/2006	–	–	–
12	rs184106436	T	A	ALLELIC	57/1995	132/4140	0.47	1	0.50
12	rs11051056	T	C	GENO	3/115/908	4/214/1918	–	–	–
12	rs11051056	T	C	ALLELIC	121/1931	222/4050	1.32	1	0.25
CHR – chromosome; A1 – minor allele; A2 – major allele; DF – degree of freedom; GENO – genotypic analysis; ALLELIC – allelic analysis.

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Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

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