Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma; Wenpei Zhang; Xiaochen Wang; Huili Jiang; Li Tang; Wen Yang; Qianyan Kang; Juan Cao

doi:10.12659/MSM.937702

30 January 2023: Clinical Research

Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma ^1ABDEF* , Wenpei Zhang ^2BC* , Xiaochen Wang ^2BC* , Huili Jiang ^3BF , Li Tang ^3BF , Wen Yang ^3BF , Qianyan Kang ^1A* , Juan Cao ^3BF

DOI: 10.12659/MSM.937702

Med Sci Monit 2023; 29:e937702

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Table 6 eQTL signals between SNP rs890069 and TRIB2 in multiple types of human tissues.

Gene	Variant ID	SNP	P-value	NES	T-statistic	Tissue
	chr2_12727378_C_T_b38	rs890069	1.90E-07	−0.16	−5.30	Adipose – Subcutaneous
	chr2_12727378_C_T_b38	rs890069	2.20E-07	−0.19	−5.30	Adipose – Visceral (Omentum)
	chr2_12727378_C_T_b38	rs890069	6.70E-05	−0.23	−4.10	Adrenal Gland
	chr2_12727378_C_T_b38	rs890069	0.0003	−0.16	−3.70	Artery – Aorta
	chr2_12727378_C_T_b38	rs890069	0.0780	−0.13	−1.80	Artery – Coronary
	chr2_12727378_C_T_b38	rs890069	0.0022	−0.09	−3.10	Artery – Tibial
	chr2_12727378_C_T_b38	rs890069	0.3100	−0.08	−1.00	Brain – Amygdala
	chr2_12727378_C_T_b38	rs890069	0.5600	0.04	0.59	Brain – Anterior cingulate cortex (BA24)
	chr2_12727378_C_T_b38	rs890069	0.0030	−0.14	−3.00	Brain – Caudate (basal ganglia)
	chr2_12727378_C_T_b38	rs890069	0.4500	0.04	0.76	Brain – Cerebellar Hemisphere
	chr2_12727378_C_T_b38	rs890069	0.9900	3.90E-04	0.01	Brain – Cerebellum
	chr2_12727378_C_T_b38	rs890069	0.0014	−0.14	−3.20	Brain – Cortex
	chr2_12727378_C_T_b38	rs890069	0.3000	−0.06	−1.00	Brain – Frontal Cortex (BA9)
	chr2_12727378_C_T_b38	rs890069	0.0590	−0.08	−1.90	Brain – Hippocampus
	chr2_12727378_C_T_b38	rs890069	0.4800	0.05	0.71	Brain – Hypothalamus
	chr2_12727378_C_T_b38	rs890069	0.4500	−0.03	−0.75	Brain – Nucleus accumbens (basal ganglia)
	chr2_12727378_C_T_b38	rs890069	0.3000	−0.05	−1.00	Brain – Putamen (basal ganglia)
	chr2_12727378_C_T_b38	rs890069	0.0810	−0.15	−1.80	Brain – Spinal cord (cervical c-1)
	chr2_12727378_C_T_b38	rs890069	0.1400	−0.12	−1.50	Brain – Substantia nigra
	chr2_12727378_C_T_b38	rs890069	9.00E-07	−0.18	−5.00	Breast – Mammary Tissue
	chr2_12727378_C_T_b38	rs890069	8.00E-10	−0.11	−6.30	Cells – Cultured fibroblasts
	chr2_12727378_C_T_b38	rs890069	0.31	−0.08	−1.00	Cells – EBV-transformed lymphocytes
	chr2_12727378_C_T_b38	rs890069	0.016	−0.12	−2.40	Colon – Sigmoid
	chr2_12727378_C_T_b38	rs890069	0.0035	−0.08	−2.90	Colon – Transverse
	chr2_12727378_C_T_b38	rs890069	0.00034	−0.10	−3.60	Esophagus – Mucosa
	chr2_12727378_C_T_b38	rs890069	6.20E-07	−0.19	−5.10	Esophagus – Muscularis
	chr2_12727378_C_T_b38	rs890069	7.3E-06	−0.18	−4.60	Heart – Atrial Appendage
	chr2_12727378_C_T_b38	rs890069	5.2E-06	−0.19	−4.60	Heart – Left Ventricle
	chr2_12727378_C_T_b38	rs890069	NaN	NaN	NaN	Kidney – Medulla
	chr2_12727378_C_T_b38	rs890069	0.022	−0.13	−2.30	Liver
	chr2_12727378_C_T_b38	rs890069	8.30E-07	−0.20	−5.00	Lung
	chr2_12727378_C_T_b38	rs890069	0.5000	−0.05	−0.67	Minor Salivary Gland
	chr2_12727378_C_T_b38	rs890069	4.10E-05	−0.13	−4.10	Muscle – Skeletal
	chr2_12727378_C_T_b38	rs890069	5.10E-08	−0.18	−5.50	Nerve – Tibial
	chr2_12727378_C_T_b38	rs890069	0.0001	−0.22	−3.90	Ovary
	chr2_12727378_C_T_b38	rs890069	5.20E-05	−0.14	−4.10	Pancreas
	chr2_12727378_C_T_b38	rs890069	4.00E-07	−0.22	−5.20	Pituitary
	chr2_12727378_C_T_b38	rs890069	0.3500	−0.05	−0.93	Prostate
	chr2_12727378_C_T_b38	rs890069	8.30E-08	−0.16	−5.50	Skin – Not Sun Exposed (Suprapubic)
	chr2_12727378_C_T_b38	rs890069	1.1E-06	−0.15	−4.90	Skin – Sun Exposed (Lower leg)
	chr2_12727378_C_T_b38	rs890069	0.0260	−0.10	−2.30	Small Intestine – Terminal Ileum
	chr2_12727378_C_T_b38	rs890069	0.0300	−0.12	−2.20	Spleen
	chr2_12727378_C_T_b38	rs890069	0.0004	−0.13	−3.60	Stomach
	chr2_12727378_C_T_b38	rs890069	0.0002	−0.10	−3.80	Testis
	chr2_12727378_C_T_b38	rs890069	0.0005	−0.14	−3.50	Thyroid
	chr2_12727378_C_T_b38	rs890069	0.4300	−0.09	−0.79	Uterus
	chr2_12727378_C_T_b38	rs890069	0.0030	−0.32	−3.00	Vagina
	chr2_12727378_C_T_b38	rs890069	2.50E-09	−0.10	−6.10	Whole Blood
NES – normalized effect size.

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Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

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