24 November 2022: Clinical Research
Multiple Cytokine Analysis of Th1/Th2/Th9/Th17/Th22/Treg Cytokine Pathway for Individual Immune Profile Assessment in Patients with Psoriasis
Anna Michalak-Stoma 1ABCDEF* , Joanna Bartosińska 2ABCDEF , Dorota Raczkiewicz 3BCDEF , Małgorzata Kowal 1ABCDE , Joanna Kozak 4BCDE , Mariusz Gujski 5CDEF , Dorota Krasowska 1ACDEF , Grażyna Chodorowska 1ADEFDOI: 10.12659/MSM.938277
Med Sci Monit 2022; 28:e938277
Table 3 Cytokine levels in patients with psoriatic arthritis and psoriatic patients without arthritis.
| Cytokine pg/ml | Patients with psoriatic arthritis (N=14) | Psoriatic patients without arthritis (N=38) | p | ||||
|---|---|---|---|---|---|---|---|
| Mean±SD | Median | Min-Max | Mean±SD | Median | Min-Max | ||
| IL-1β | 1.79±1.24 | 1.53 | 0.51–4.41 | 1.68±1.02 | 1.53 | 0.51–4.41 | 0.967 |
| IL-4 | 14.18±5.49 | 14.30 | 7.20–27.53 | 12.41±5.30 | 12.38 | 3.22–22.53 | 0.327 |
| IL-6 | 28.28±15.56 | 25.74 | 6.48–67.93 | 36.56±17.13 | 33.12 | 8.63–71.72 | 0.122 |
| IL-9 | 105.62±53.20 | 95.28 | 7.70–224.04 | 170.08±104.02 | 145.21 | 18.41–489.60 | * |
| IL-12p70 | 1.88±0.21 | 1.86 | 1.44–2.23 | 1.92±0.34 | 1.86 | 1.44–2.57 | 0.877 |
| IL-18 | 103.40±40.22 | 80.35 | 63.27–182.51 | 96.08±47.12 | 85.10 | 22.45–217.94 | 0.643 |
| IL-23 | 10.38±7.01 | 10.25 | 0.83–24.53 | 18.37±21.03 | 10.25 | 0.83–77.22 | 0.550 |
| IL-27 | 39.05±29.91 | 21.73 | 20.95–115.36 | 40.47±37.94 | 21.34 | 20.95–191.70 | 0.749 |
| TNF alpha | 2.31±0.91 | 2.23 | 0.90–4.32 | 2.33±0.86 | 2.23 | 0.90–4.32 | 0.893 |
| IFN gamma | 26.71±9.53 | 26.23 | 11.83–40.44 | 27.21±11.74 | 23.76 | 9.41–50.07 | 0.951 |
| * Statistically significant. | |||||||